The Rockefeller University - Nova-Dependent Regulation of Brain-Specific Splicing


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	Nova-2 Regulated Network

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Validated Exons

Page 2 of 2	Showing rows 31 - 53 (53 total)
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Symbol

Name in Fig.4

Gene Name

Synaptic Function

Interaction Partners

Exon

Nova-2 wt/ko cortex

Nova-1 wt/ko sc

cx/sc

brain/ non-brain

ΔI

Fold Change

ΔI

Chip

PCR

Chip

PCR

sort

Grik2

GluR6

ionotropic glutamate receptor, kainate 2, beta 2 (GluR6)

Neurotransmitter receptor 17

CASK

E16a

-0.13

0.22

2.80

0.06

0.25

0.74

Grin1

NMDA R1

ionotropic glutamate receptor NMDA1 (NR1)

Neurotransmitter receptor 24

CaMKIIg

E19

0.25

0.32

5.00

0.06

0.00

0.45

0.46

Idh3b

isocitrate dehydrogenase 3 (NAD+) beta

E12

0.46

0.27

0.53

15.00

0.02

0.06

0.05

0.00

Igsf4a

Syncam

immunoglobulin superfamily, member 4A (SynCam)

Cell-cell adhesion 32

CASK ; 4.1B

-0.36

0.38

0.23

7.00

0.03

0.15

0.05

0.48

Kcnma1

Slo

potassium large conductance calcium-activated channel M, alpha 1 (Slo, MaxiK, BK)

Neurotransmiter release 30

E24a

0.34

0.36

0.40

6.00

0.00

0.09

Kcnq2

KCNQ2

potassium voltage-gated channel, subfamily Q, member 2

Neurotransmiter release 19

Ankyrin G

E13

0.26

0.18

2.70

0.02

0.59

Lrp12

low density lipoprotein-related protein 12 / suppression of tumorigenicity 7 (St7)

0.30

0.63

19.00

0.01

0.06

0.24

0.55

Lrp1b

low density lipoprotein-related protein 1B (deleted in tumors)

E79

0.21

0.39

0.47

11.00

0.03

0.02

0.06

Map4k4

Nik/Map4k4

mitogen-activated protein kinase kinase kinase kinase 4 / NCK interacting kinase (Nik)

Signaling 23

JNK2

E22a

-0.15

0.29

0.15

2.10

0.23

Mapk9

JNK2

mitogen activated protein kinase 9 (JNK2)

Signaling 23

APLP2 ; Nik

E6a

0.42

6.28

0.00

0.32

0.58

Ncdn

neurochondrin

-0.31

0.29

0.26

17.00

0.06

0.04

0.18

0.25

Neo1

neogenin

Axon guidance 36

E27

0.69

34.00

0.24

0.02

0.53

Ntng1

netrin G1

Axon guidance 22

E5a

0.32

0.26

3.50

0.04

0.05

Plcb4

PLCb4

phospholipase C, beta 4

Signaling 26

E36a

-0.25

0.31

0.64

22.00

0.03

0.07

0.02

0.73

Ptprf

LAR

protein tyrosine phosphatase receptor type F (LAR)

Receptor localization 20

E19a

0.47

0.58

0.61

18.00

0.01

0.12

0.24

Rap1ga1

Rap1GAP

Rap1, GTPase-activating protein 1

Signaling 28

E27

-0.44

0.47

0.33

5.00

0.03

0.18

Skip

sphingosine kinase type 1-interacting protein

E10

0.41

0.35

0.26

9.00

0.16

0.21

0.19

Spna2

spectrin a2

spectrin alpha 2

Receptor localization 31

Ankyrin G ; Catenin a2 ; Spectrin 4.1R, 4.1G, 4.1B

0.36

0.35

0.46

12.00

0.06

0.2

Srr

serine racemase

NMDA receptor regulation 29

-0.37

0.25

0.49

15.00

0.08

0.00

0.56

0.41

Stxbp2

Munc18

syntaxin binding protein 2 (Munc18)

Neurotransmiter release 21

CASK

-0.14

0.16

0.22

2.80

0.00

0.06

0.25

0.74

Tacc2

transforming, acidic coiled-coil containing protein

E10

0.36

0.19

0.38

5.00

0.13

0.07

0.41

0.63

Tpm3

tropomyosin 3, gamma

Cytoskeleton binding 33

E6a

0.24

0.31

0.43

7.00

0.18

0.53

Tpm3

tropomyosin 3, gamma

Cytoskeleton binding 33

-0.31

0.35

0.43

7.00

0.6

Page 2 of 2	Showing rows 31 - 53 (53 total)
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References

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