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Validated Exons
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Page 1 of 2
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Showing rows 1 - 30 (53 total)
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| Symbol |
Name in Fig.4 |
Gene Name |
Synaptic Function |
Interaction Partners |
Exon |
Nova-2 wt/ko cortex |
Nova-1 wt/ko sc |
cx/sc |
brain/ non-brain |
| ΔI |
Fold Change |
ΔI |
| Chip |
Chip |
PCR |
PCR |
Chip |
PCR |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Tpm3
|
Tpm3
|
tropomyosin 3, gamma
|
Cytoskeleton binding 33
|
|
E6a
|
0.24
|
0.31
|
0.43
|
 |
7.00 |
|
|
|
|
0.53
|
|
Tpm3
|
Tpm3
|
tropomyosin 3, gamma
|
Cytoskeleton binding 33
|
|
E6
|
-0.31
|
|
|
 |
7.00 |
|
|
|
|
|
|
Tacc2
|
|
transforming, acidic coiled-coil containing protein
|
|
|
E10
|
0.36
|
0.19
|
0.38
|
|
5.00 |
|
0.13
|
0.07
|
0.41
|
0.63
|
|
Stxbp2
|
Munc18
|
syntaxin binding protein 2 (Munc18)
|
Neurotransmiter release 21
|
CASK
|
E3
|
-0.14
|
|
|
|
2.80 |
|
0.00
|
0.06
|
|
|
|
Srr
|
|
serine racemase
|
NMDA receptor regulation 29
|
|
E2
|
-0.37
|
|
|
|
15.00 |
|
|
0.00
|
|
|
|
Spna2
|
spectrin a2
|
spectrin alpha 2
|
Receptor localization 31
|
Ankyrin G ; Catenin a2 ; Spectrin 4.1R, 4.1G, 4.1B
|
E4
|
0.36
|
0.35
|
0.46
|
|
12.00 |
|
0.06
|
|
|
|
|
Skip
|
Skip
|
sphingosine kinase type 1-interacting protein
|
|
|
E10
|
0.41
|
0.35
|
0.26
|
|
9.00 |
|
0.16
|
0.21
|
|
0.19
|
|
Rap1ga1
|
Rap1GAP
|
Rap1, GTPase-activating protein 1
|
Signaling 28
|
|
E27
|
-0.44
|
|
|
|
5.00 |
|
|
|
0.18
|
|
|
Ptprf
|
LAR
|
protein tyrosine phosphatase receptor type F (LAR)
|
Receptor localization 20
|
|
E19a
|
0.47
|
0.58
|
0.61
|
|
18.00 |
|
|
|
0.12
|
0.24
|
|
Plcb4
|
PLCb4
|
phospholipase C, beta 4
|
Signaling 26
|
|
E36a
|
-0.25
|
|
|
|
22.00 |
|
|
|
0.02
|
|
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Ntng1
|
netrin G1
|
netrin G1
|
Axon guidance 22
|
|
E5a
|
|
|
|
|
3.50 |
|
|
0.04
|
|
|
|
Neo1
|
neogenin
|
neogenin
|
Axon guidance 36
|
|
E27
|
|
|
|
|
34.00 |
|
|
|
0.02
|
|
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Ncdn
|
|
neurochondrin
|
|
|
E1
|
-0.31
|
|
|
|
17.00 |
|
|
|
|
|
|
Mapk9
|
JNK2
|
mitogen activated protein kinase 9 (JNK2)
|
Signaling 23
|
APLP2 ; Nik
|
E6a
|
|
|
0.42
|
|
6.28 |
|
|
0.00
|
|
0.58
|
|
Map4k4
|
Nik/Map4k4
|
mitogen-activated protein kinase kinase kinase kinase 4 / NCK interacting kinase (Nik)
|
Signaling 23
|
JNK2
|
E22a
|
-0.15
|
|
|
|
2.10 |
|
|
|
|
|
|
Lrp1b
|
|
low density lipoprotein-related protein 1B (deleted in tumors)
|
|
|
E79
|
0.21
|
0.39
|
0.47
|
|
11.00 |
|
0.03
|
0.02
|
0.06
|
|
|
Lrp12
|
|
low density lipoprotein-related protein 12 / suppression of tumorigenicity 7 (St7)
|
|
|
E7
|
|
0.30
|
0.63
|
|
19.00 |
|
|
0.06
|
0.24
|
0.55
|
|
Kcnq2
|
KCNQ2
|
potassium voltage-gated channel, subfamily Q, member 2
|
Neurotransmiter release 19
|
Ankyrin G
|
E13
|
0.26
|
|
0.18
|
|
2.70 |
|
|
|
0.59
|
|
|
Kcnma1
|
Slo
|
potassium large conductance calcium-activated channel M, alpha 1 (Slo, MaxiK, BK)
|
Neurotransmiter release 30
|
|
E24a
|
0.34
|
0.36
|
0.40
|
|
6.00 |
|
|
0.00
|
|
|
|
Igsf4a
|
Syncam
|
immunoglobulin superfamily, member 4A (SynCam)
|
Cell-cell adhesion 32
|
CASK ; 4.1B
|
E8
|
-0.36
|
|
|
|
7.00 |
|
|
|
|
|
|
Idh3b
|
|
isocitrate dehydrogenase 3 (NAD+) beta
|
|
|
E12
|
0.46
|
0.27
|
0.53
|
|
15.00 |
|
|
|
0.05
|
0.00
|
|
Grin1
|
NMDA R1
|
ionotropic glutamate receptor NMDA1 (NR1)
|
Neurotransmitter receptor 24
|
CaMKIIg
|
E19
|
|
0.25
|
0.32
|
|
5.00 |
|
0.06
|
0.00
|
0.45
|
0.46
|
|
Grik2
|
GluR6
|
ionotropic glutamate receptor, kainate 2, beta 2 (GluR6)
|
Neurotransmitter receptor 17
|
CASK
|
E16a
|
-0.13
|
|
|
|
2.80 |
|
|
0.06
|
|
|
|
Gpr45
|
|
G protein-coupled receptor 45
|
|
|
E2
|
-0.30
|
|
|
|
50.00 |
|
0.01
|
0.08
|
0.00
|
|
|
Gphn
|
gephyrin
|
gephyrin
|
Receptor localization 16
|
GABAARg2 ; GlyRa2
|
E7a
|
|
|
|
|
59.00 |
|
|
|
|
|
|
Golga4
|
|
golgi autoantigen, golgin subfamily a 4 (golgin-245)
|
|
|
E22a
|
0.25
|
0.23
|
0.08
|
|
5.00 |
|
0.05
|
0.02
|
0.03
|
0.15
|
|
Glra2
|
GlyRa2
|
glycine receptor, alpha 2 subunit
|
Neurotransmitter receptor 35
|
Gephyrin
|
|
|
|
|
|
|
|
|
|
|
Gabrg2
|
GABAARg2
|
gamma-aminobutyric acid (GABA-A) receptor gamma 2 subunit
|
Neurotransmitter receptor 34
|
Gephyrin
|
|
|
|
0.10
|
|
4.29 |
|
|
0.18
|
|
|
|
Falz
|
|
fetal Alzheimer antigen / nucleosome remodeling factor, large subunit (FAC1/BPTF/NURF301)
|
Transcription 25
|
|
E4
|
0.22
|
0.22
|
0.13
|
|
5.00 |
|
0.14
|
0.11
|
0.04
|
0.16
|
|
Epim
|
syntaxin 2
|
epimorphin (Syntaxin 2)
|
|
|
E10
|
-0.18
|
|
|
|
7.00 |
|
|
|
0.20
|
|
|
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Page 1 of 2
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Showing rows 1 - 30 (53 total)
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References
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Voltage-gated sodium channels and ankyrinG occupy a different postsynaptic domain from acetylcholine receptors from an early stage of neuromuscular junction maturation in rats. J Neurosci 23, 2102-11 (2003). Back to Table | | 6. | Herms, J. et al. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. Embo J 23, 4106-15 (2004). Back to Table | | 7. | Vogt, L. et al. Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol Cell Neurosci 17, 151-66 (2001). Back to Table | | 8. | Rongo, C. & Kaplan, J. M. CaMKII regulates the density of central glutamatergic synapses in vivo. Nature 402, 195-9 (1999). Back to Table | | 9. | Butz, S., Okamoto, M. & Sudhof, T. C. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell 94, 773-82 (1998). Back to Table | | 10. | Abe, K., Chisaka, O., Van Roy, F. & Takeichi, M. Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. Nat Neurosci 7, 357-63 (2004). Back to Table | | 11. | Wang, Z. W., Saifee, O., Nonet, M. L. & Salkoff, L. SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction. Neuron 32, 867-81 (2001). Back to Table | | 12. | Lee, H. et al. The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. Neuron 42, 913-26 (2004). Back to Table | | 13. | Naus, S. et al. Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J Biol Chem 279, 16083-90 (2004). Back to Table | | 14. | Himanen, J. P. et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci 7, 501-9 (2004). Back to Table | | 15. | Wong, E. V., Kerner, J. A. & Jay, D. G. Convergent and divergent signaling mechanisms of growth cone collapse by ephrinA5 and slit2. J Neurobiol 59, 66-81 (2004). Back to Table | | 16. | Kneussel, M. et al. Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes. Mol Cell Neurosci 17, 973-82 (2001). Back to Table | | 17. | Contractor, A., Swanson, G. & Heinemann, S. F. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron 29, 209-16 (2001). Back to Table | | 18. | Suzuki, T. et al. Presence of molecular chaperones, heat shock cognate (Hsc) 70 and heat shock proteins (Hsp) 40, in the postsynaptic structures of rat brain. Brain Res 816, 99-110 (1999). Back to Table | | 19. | Martire, M. et al. M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. J Neurosci 24, 592-7 (2004). Back to Table | | 20. | Yang, T. et al. 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