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Validated Exons
Page 1 of 2
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Showing rows 1 - 30 (53 total)
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Symbol |
Name in Fig.4 |
Gene Name |
Synaptic Function |
Interaction Partners |
Exon |
Nova-2 wt/ko cortex |
Nova-1 wt/ko sc |
cx/sc |
brain/ non-brain |
ΔI |
Fold Change |
ΔI |
Chip |
Chip |
PCR |
PCR |
Chip |
PCR |
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Atp2b1
|
PMCA1
|
ATPase, Ca++ transporting, plasma membrane 1 (PMCA1)
|
Neurotransmiter release 27
|
CASK
|
E34
|
0.61
|
0.61
|
0.47
|
|
23.82 |
|
|
0.18
|
0.15
|
0.95
|
Camk2g
|
CaMKIIg
|
calcium/calmodulin -dependent protein kinase II gamma
|
Neurotransmiter release 9
|
CASK ; NMDAR
|
E13a
|
0.28
|
0.30
|
0.28
|
|
3.20 |
|
|
|
|
0.59
|
Catna2
|
catenin a2
|
catenin alpha 2
|
Neurotransmiter release 11
|
Spectrin a2
|
E17a
|
-0.25
|
|
|
|
12.00 |
|
|
|
|
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Efna5
|
ephrinA5
|
ephrin A5
|
Cell-cell adhesion 14
|
EphrinA5R
|
E3a
|
-0.23
|
|
|
|
3.00 |
|
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0.03
|
|
|
Gabrg2
|
GABAARg2
|
gamma-aminobutyric acid (GABA-A) receptor gamma 2 subunit
|
Neurotransmitter receptor 34
|
Gephyrin
|
|
|
|
0.10
|
|
4.29 |
|
|
0.18
|
|
|
Glra2
|
GlyRa2
|
glycine receptor, alpha 2 subunit
|
Neurotransmitter receptor 35
|
Gephyrin
|
|
|
|
|
|
|
|
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Grik2
|
GluR6
|
ionotropic glutamate receptor, kainate 2, beta 2 (GluR6)
|
Neurotransmitter receptor 17
|
CASK
|
E16a
|
-0.13
|
|
|
|
2.80 |
|
|
0.06
|
|
|
Kcnq2
|
KCNQ2
|
potassium voltage-gated channel, subfamily Q, member 2
|
Neurotransmiter release 19
|
Ankyrin G
|
E13
|
0.26
|
|
0.18
|
|
2.70 |
|
|
|
0.59
|
|
Map4k4
|
Nik/Map4k4
|
mitogen-activated protein kinase kinase kinase kinase 4 / NCK interacting kinase (Nik)
|
Signaling 23
|
JNK2
|
E22a
|
-0.15
|
|
|
|
2.10 |
|
|
|
|
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Mapk9
|
JNK2
|
mitogen activated protein kinase 9 (JNK2)
|
Signaling 23
|
APLP2 ; Nik
|
E6a
|
|
|
0.42
|
|
6.28 |
|
|
0.00
|
|
0.58
|
Agrn
|
agrin
|
agrin
|
Receptor localization 4
|
|
E31a
|
0.40
|
0.45
|
0.24
|
|
8.00 |
|
|
|
|
0.29
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Arhgap21
|
Arhgap21
|
Rho GTPase activating protein 21
|
|
|
E8
|
0.37
|
0.42
|
0.18
|
|
2.30 |
|
|
0.01
|
0.19
|
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Clasp1
|
Clasp1
|
CLIP associating protein 1
|
Cytoskeleton binding 12
|
|
E9
|
0.37
|
0.34
|
0.44
|
|
7.00 |
|
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0.03
|
0.20
|
0.62
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Clstn1
|
calsyntenin 1
|
calsyntenin 1
|
Signaling 7
|
|
E10
|
0.34
|
0.39
|
0.40
|
|
27.00 |
|
|
0.00
|
0.01
|
0.66
|
Dnajb5
|
|
DnaJ (Hsp40) homolog, subfamily B, member 5
|
Chaperone 18
|
|
E1a
|
0.35
|
0.33
|
0.12
|
|
51.00 |
|
|
0.00
|
0.12
|
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Kcnma1
|
Slo
|
potassium large conductance calcium-activated channel M, alpha 1 (Slo, MaxiK, BK)
|
Neurotransmiter release 30
|
|
E24a
|
0.34
|
0.36
|
0.40
|
|
6.00 |
|
|
0.00
|
|
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Neo1
|
neogenin
|
neogenin
|
Axon guidance 36
|
|
E27
|
|
|
|
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34.00 |
|
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|
0.02
|
|
Ntng1
|
netrin G1
|
netrin G1
|
Axon guidance 22
|
|
E5a
|
|
|
|
|
3.50 |
|
|
0.04
|
|
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Ptprf
|
LAR
|
protein tyrosine phosphatase receptor type F (LAR)
|
Receptor localization 20
|
|
E19a
|
0.47
|
0.58
|
0.61
|
|
18.00 |
|
|
|
0.12
|
0.24
|
Tpm3
|
Tpm3
|
tropomyosin 3, gamma
|
Cytoskeleton binding 33
|
|
E6a
|
0.24
|
0.31
|
0.43
|
|
7.00 |
|
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0.53
|
Tpm3
|
Tpm3
|
tropomyosin 3, gamma
|
Cytoskeleton binding 33
|
|
E6
|
-0.31
|
|
|
|
7.00 |
|
|
|
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Srr
|
|
serine racemase
|
NMDA receptor regulation 29
|
|
E2
|
-0.37
|
|
|
|
15.00 |
|
|
0.00
|
|
|
Ncdn
|
|
neurochondrin
|
|
|
E1
|
-0.31
|
|
|
|
17.00 |
|
|
|
|
|
Gphn
|
gephyrin
|
gephyrin
|
Receptor localization 16
|
GABAARg2 ; GlyRa2
|
E7a
|
|
|
|
|
59.00 |
|
|
|
|
|
Chl1
|
Chl1
|
close homolog of L1
|
Cell-cell adhesion 13
|
Ankyrin G
|
E7a
|
-0.57
|
|
|
|
127.00 |
|
|
0.02
|
|
|
Igsf4a
|
Syncam
|
immunoglobulin superfamily, member 4A (SynCam)
|
Cell-cell adhesion 32
|
CASK ; 4.1B
|
E8
|
-0.36
|
|
|
|
7.00 |
|
|
|
|
|
Plcb4
|
PLCb4
|
phospholipase C, beta 4
|
Signaling 26
|
|
E36a
|
-0.25
|
|
|
|
22.00 |
|
|
|
0.02
|
|
Rap1ga1
|
Rap1GAP
|
Rap1, GTPase-activating protein 1
|
Signaling 28
|
|
E27
|
-0.44
|
|
|
|
5.00 |
|
|
|
0.18
|
|
Cacna1b
|
Cav2.2
|
calcium channel, voltage-dependent, N type, alpha 1B subunit (Cav2.2)
|
Signaling 8
|
CASK
|
E24a
|
0.59
|
0.51
|
0.46
|
|
9.00 |
|
|
0.04
|
|
|
Idh3b
|
|
isocitrate dehydrogenase 3 (NAD+) beta
|
|
|
E12
|
0.46
|
0.27
|
0.53
|
|
15.00 |
|
|
|
0.05
|
0.00
|
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Page 1 of 2
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Showing rows 1 - 30 (53 total)
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References
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Voltage-gated sodium channels and ankyrinG occupy a different postsynaptic domain from acetylcholine receptors from an early stage of neuromuscular junction maturation in rats. J Neurosci 23, 2102-11 (2003). Back to Table | 6. | Herms, J. et al. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. Embo J 23, 4106-15 (2004). Back to Table | 7. | Vogt, L. et al. Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol Cell Neurosci 17, 151-66 (2001). Back to Table | 8. | Rongo, C. & Kaplan, J. M. CaMKII regulates the density of central glutamatergic synapses in vivo. Nature 402, 195-9 (1999). Back to Table | 9. | Butz, S., Okamoto, M. & Sudhof, T. C. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell 94, 773-82 (1998). Back to Table | 10. | Abe, K., Chisaka, O., Van Roy, F. & Takeichi, M. Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. Nat Neurosci 7, 357-63 (2004). Back to Table | 11. | Wang, Z. W., Saifee, O., Nonet, M. L. & Salkoff, L. SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction. Neuron 32, 867-81 (2001). Back to Table | 12. | Lee, H. et al. The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. Neuron 42, 913-26 (2004). Back to Table | 13. | Naus, S. et al. Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J Biol Chem 279, 16083-90 (2004). Back to Table | 14. | Himanen, J. P. et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci 7, 501-9 (2004). Back to Table | 15. | Wong, E. V., Kerner, J. A. & Jay, D. G. Convergent and divergent signaling mechanisms of growth cone collapse by ephrinA5 and slit2. J Neurobiol 59, 66-81 (2004). Back to Table | 16. | Kneussel, M. et al. Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes. Mol Cell Neurosci 17, 973-82 (2001). Back to Table | 17. | Contractor, A., Swanson, G. & Heinemann, S. F. Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus. Neuron 29, 209-16 (2001). Back to Table | 18. | Suzuki, T. et al. Presence of molecular chaperones, heat shock cognate (Hsc) 70 and heat shock proteins (Hsp) 40, in the postsynaptic structures of rat brain. Brain Res 816, 99-110 (1999). Back to Table | 19. | Martire, M. et al. M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. J Neurosci 24, 592-7 (2004). Back to Table | 20. | Yang, T. et al. Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. J Neurosci 23, 3353-63 (2003). Back to Table | 21. | Hata, Y., Slaughter, C. A. & Sudhof, T. C. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366, 347-51 (1993). Back to Table | 22. | Lin, J. C., Ho, W. H., Gurney, A. & Rosenthal, A. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Nat Neurosci 6, 1270-6 (2003). Back to Table | 23. | Poinat, P. et al. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Curr Biol 12, 622-31 (2002). Back to Table | 24. | Morris, R. G., Anderson, E., Lynch, G. S. & Baudry, M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319, 774-6 (1986). 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Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release. J Neurosci 21, 9585-97 (2001). Back to Table | 31. | Schmitz, F. Immunological heterogeneity of synaptic and extrasynaptic forms of non-erythroid alpha-spectrin in the rat retina. Neurosci Lett 313, 25-8 (2001). Back to Table | 32. | Biederer, T. et al. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297, 1525-31 (2002). Back to Table | 33. | Had, L. et al. Tropomyosin isoforms in rat neurons: the different developmental profiles and distributions of TM-4 and TMBr-3 are consistent with different functions. J Cell Sci 107 ( Pt 10), 2961-73 (1994). Back to Table | 34. | Lorez, M., Benke, D., Luscher, B., Mohler, H. & Benson, J. A. Single-channel properties of neuronal GABAA receptors from mice lacking the 2 subunit. J Physiol 527 Pt 1, 11-31 (2000). Back to Table | 35. | Mangin, J. M. et al. Kinetic properties of the alpha2 homo-oligomeric glycine receptor impairs a proper synaptic functioning. J Physiol 553, 369-86 (2003). Back to Table | 36. | Rajagopalan, S. et al. Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 6, 756-62 (2004). Back to Table | |
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