| Connectivity | 51 |
|---|---|
| Notes | Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. |
| Hugo ID | 3225 |
| Name | EFNA5 |
| Description | ephrin-A5 |
| URN | urn:agi-llid:1946 |
| GO Cellular Component | membrane |
|---|---|
| extracellular space | |
| extrinsic to plasma membrane, GPI-anchored |
| Cell Localization | Extracellular |
|---|---|
| Plasma membrane |
| GO Biological Process | brain development |
|---|---|
| central nervous system development | |
| development | |
| fasciculation of neuron | |
| neurogenesis | |
| cell-cell signaling |
| Microarray ID | 1369594_at |
|---|---|
| U69279_at | |
| A_43_P12976 | |
| NM_053903 | |
| 99887_at | |
| 1421796_a_at | |
| A_51_P218009 | |
| NM_010109 | |
| U26403 | |
| 207301_at | |
| 1041_at | |
| U26403_at | |
| A_23_P167497 | |
| I_957318 |
| GenBank ID | U69279 |
|---|---|
| NW_047818 | |
| NM_053903 | |
| NP_446355 | |
| AAC05801 | |
| U90665 | |
| NT_039657 | |
| NM_010109 | |
| NP_034239 | |
| BC040218 | |
| AAH40218 | |
| U90664 | |
| AAB50239 | |
| AAB50240 | |
| O08543 | |
| U26403 | |
| NT_034772 | |
| NM_001962 | |
| NP_001953 | |
| AAB60377 | |
| P52803 |
| State | isoform 2 |
|---|---|
| isoform 1 |
| MGI ID | 107444 |
|---|
| GO Molecular Function | ephrin receptor binding |
|---|
| GO ID | GO:0007275 |
|---|---|
| GO:0007399 | |
| GO:0016020 | |
| GO:0005615 | |
| GO:0046875 | |
| GO:0007267 | |
| GO:0046658 |
| Swiss-Prot Accession | P52803 |
|---|
| OMIM ID | OMIM:601535 |
|---|
| Alias | Efna5 |
|---|---|
| Lerk7 | |
| eph-related receptor tyrosine kinase ligand 7 | |
| AL-1 | |
| Epl7 | |
| RAGS | |
| EFL-5 | |
| LERK-7 | |
| Ephrin-A5 | |
| ephrin A5 | |
| AF1 | |
| EFL5 | |
| EPLG7 | |
| EPH-related receptor tyrosine kinase ligand VII | |
| LERK VII | |
| AL I |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 116683 |
|---|---|
| 13640 | |
| 1946 |
| Source | ResNet |
|---|
| RGD ID | 620391 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.10714 |
|---|---|
| Mm.7978 | |
| Hs.437840 | |
| Hs.37142 |
| Group | Ligands |
|---|---|
| receptor binding |