Protein : APBA2

Connectivity 29
Notes The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
Hugo ID 579
Name APBA2
Description amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)
URN urn:agi-llid:321

GO Cellular Component plasma membrane

Cell Localization Plasma membrane
Cytoplasm

GO Biological Process intracellular protein transport
intracellular signaling cascade
protein transport
synaptic vesicle exocytosis
neurogenesis
pathogenesis

Microarray ID 1375616_at
1387289_at
AF029107_at
A_43_P12675
NM_031780
92727_at
1427288_at
L34676_rc_at
Msa.1599.0_at
A_51_P173851
L34676
AB014719
209870_s_at
39590_at
209871_s_at
RC_T16098_s_at
RC_AA598991_at
U79255_at
A_23_P158231
I_1221912

GenBank ID AF029107
NW_047559
NM_031780
NP_113968
AAC05305
BC057620
NT_039425
XM_133532
XP_133532
AAH57620
BC060269
AAH60269
L34676
AAA73936
P98084
NP_031487
AB014719
AF047348
NT_010194
NM_005503
NP_005494
BAA34734
AF029108
AAC05306
AAC39767
BC007794
U79255
AAB50203
Q99767

MGI ID 1261791

GO Molecular Function protein transporter activity
protein binding
amyloid protein

GO ID GO:0008565
GO:0015031
GO:0006886
GO:0007242
GO:0005515
GO:0005208
GO:0009405
GO:0007399

Swiss-Prot Accession Q99767

OMIM ID OMIM:602712

Alias Apba2
Mint2
amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like)
X11L
X11-like
amyloid beta (A4) precursor protein-binding, family A, member 2
LIN-10
X11-like protein
adapter protein X11beta
neuron-specific X11L protein
neuronal munc18-1-interacting protein 2
amyloid beta A4 precursor protein-binding, family A, member 2
phosphotyrosine-binding/-interacting domain (PTB)-bearing protein
HsT16821
D15S1518E
MGC:14091
LIN X
Mint II
Mint-2
Munc18-1-interacting protein 2
Munc18-1-interacting protein II
Munc18-1-interactive protein 2
Munc18-1-interactive protein II
Neuron- specific X11L protein
Neuronal Munc18-1-interacting protein II
Neuronal Munc18-1-interactive protein 2
Neuronal Munc18-1-interactive protein II

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 83610
11784
321
9029

Source ResNet

RGD ID 620845

Pathway path
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.62687
Mm.4657
Hs.26468

Group protein binding
New Group