Connectivity | 29 |
---|---|
Notes | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. |
Hugo ID | 579 |
Name | APBA2 |
Description | amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like) |
URN | urn:agi-llid:321 |
GO Cellular Component | plasma membrane |
---|
Cell Localization | Plasma membrane |
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Cytoplasm |
GO Biological Process | intracellular protein transport |
---|---|
intracellular signaling cascade | |
protein transport | |
synaptic vesicle exocytosis | |
neurogenesis | |
pathogenesis |
Microarray ID | 1375616_at |
---|---|
1387289_at | |
AF029107_at | |
A_43_P12675 | |
NM_031780 | |
92727_at | |
1427288_at | |
L34676_rc_at | |
Msa.1599.0_at | |
A_51_P173851 | |
L34676 | |
AB014719 | |
209870_s_at | |
39590_at | |
209871_s_at | |
RC_T16098_s_at | |
RC_AA598991_at | |
U79255_at | |
A_23_P158231 | |
I_1221912 |
MGI ID | 1261791 |
---|
GO Molecular Function | protein transporter activity |
---|---|
protein binding | |
amyloid protein |
GO ID | GO:0008565 |
---|---|
GO:0015031 | |
GO:0006886 | |
GO:0007242 | |
GO:0005515 | |
GO:0005208 | |
GO:0009405 | |
GO:0007399 |
Swiss-Prot Accession | Q99767 |
---|
OMIM ID | OMIM:602712 |
---|
Alias | Apba2 |
---|---|
Mint2 | |
amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like) | |
X11L | |
X11-like | |
amyloid beta (A4) precursor protein-binding, family A, member 2 | |
LIN-10 | |
X11-like protein | |
adapter protein X11beta | |
neuron-specific X11L protein | |
neuronal munc18-1-interacting protein 2 | |
amyloid beta A4 precursor protein-binding, family A, member 2 | |
phosphotyrosine-binding/-interacting domain (PTB)-bearing protein | |
HsT16821 | |
D15S1518E | |
MGC:14091 | |
LIN X | |
Mint II | |
Mint-2 | |
Munc18-1-interacting protein 2 | |
Munc18-1-interacting protein II | |
Munc18-1-interactive protein 2 | |
Munc18-1-interactive protein II | |
Neuron- specific X11L protein | |
Neuronal Munc18-1-interacting protein II | |
Neuronal Munc18-1-interactive protein 2 | |
Neuronal Munc18-1-interactive protein II |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 83610 |
---|---|
11784 | |
321 | |
9029 |
Source | ResNet |
---|
RGD ID | 620845 |
---|
Pathway | path |
---|---|
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.62687 |
---|---|
Mm.4657 | |
Hs.26468 |
Group | protein binding |
---|---|
New Group |