Connectivity | 373 |
---|---|
Notes | Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM] |
Hugo ID | 4390 |
Name | GNAQ |
Description | guanine nucleotide binding protein (G protein), q polypeptide |
URN | urn:agi-llid:2776 |
GO Cellular Component | heterotrimeric G-protein complex |
---|---|
cytoplasm | |
plasma membrane |
Cell Localization | Cytoplasm |
---|---|
Plasma membrane |
GO Biological Process | G-protein coupled receptor protein signaling pathway |
---|---|
signal transduction | |
G-protein signaling, adenylate cyclase activating pathway | |
glutamate signaling pathway | |
heart development | |
neuronal remodeling | |
protein amino acid ADP-ribosylation | |
regulation of action potential | |
skeletal development | |
phospholipase C activation |
MGI ID | 95776 |
---|
Swiss-Prot Accession | P50148 |
---|
OMIM ID | OMIM:600998 |
---|
Alias | Gnaq |
---|---|
heterotrimeric guanine nucleotide-binding protein alpha q subunit | |
Gq | |
Galphaq | |
guanine nucleotide binding protein, alpha q polypeptide | |
G alpha q | |
1110005L02Rik | |
6230401I02Rik | |
G-ALPHA-q | |
guanine nucleotide binding protein (G protein), q polypeptide | |
G(q), alpha | |
G(q), alpha subunit | |
Guanine nucleotide-binding protein G(q), alpha subunit | |
heterotrimeric guanine nucleotide-binding protein alpha q subuni | |
RIKEN cDNA 1110005L02 gene | |
RIKEN cDNA 6230401I02 gene | |
GAQ | |
G protein q polypeptide | |
(G PROTEIN), Q POLYPEPTIDE |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 81666 |
---|---|
14682 | |
67782 | |
71788 | |
107077 | |
107345 | |
158254 |
RGD ID | 620770 |
---|
Pathway | Copy of 'path8' |
---|---|
path8 | |
pathfeb |
Unigene ID | Rn.22817 |
---|---|
Mm.275685 | |
Hs.469951 |
Group | nucleotide binding |
---|---|
New Group |