Protein : GNAQ

Connectivity 373
Notes Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM]
Hugo ID 4390
Name GNAQ
Description guanine nucleotide binding protein (G protein), q polypeptide
URN urn:agi-llid:2776

GO Cellular Component heterotrimeric G-protein complex
cytoplasm
plasma membrane

Cell Localization Cytoplasm
Plasma membrane

GO Biological Process G-protein coupled receptor protein signaling pathway
signal transduction
G-protein signaling, adenylate cyclase activating pathway
glutamate signaling pathway
heart development
neuronal remodeling
protein amino acid ADP-ribosylation
regulation of action potential
skeletal development
phospholipase C activation

MGI ID 95776

Swiss-Prot Accession P50148

OMIM ID OMIM:600998

Alias Gnaq
heterotrimeric guanine nucleotide-binding protein alpha q subunit
Gq
Galphaq
guanine nucleotide binding protein, alpha q polypeptide
G alpha q
1110005L02Rik
6230401I02Rik
G-ALPHA-q
guanine nucleotide binding protein (G protein), q polypeptide
G(q), alpha
G(q), alpha subunit
Guanine nucleotide-binding protein G(q), alpha subunit
heterotrimeric guanine nucleotide-binding protein alpha q subuni
RIKEN cDNA 1110005L02 gene
RIKEN cDNA 6230401I02 gene
GAQ
G protein q polypeptide
(G PROTEIN), Q POLYPEPTIDE

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 81666
14682
67782
71788
107077
107345
158254

RGD ID 620770

Pathway Copy of 'path8'
path8
pathfeb

Unigene ID Rn.22817
Mm.275685
Hs.469951

Group nucleotide binding
New Group