Connectivity | 14 |
---|---|
Notes | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. |
Hugo ID | 3389 |
Name | EPHA5 |
Description | EphA5 |
URN | urn:agi-llid:2044 |
GO Cellular Component | integral to membrane |
---|---|
membrane |
Cell Localization | Plasma membrane |
---|
GO Biological Process | protein amino acid phosphorylation |
---|---|
transmembrane receptor protein tyrosine kinase signaling pathway |
EC Number | 2.7.1.112 |
---|
Microarray ID | 1371007_at |
---|---|
rc_AI231376_at | |
X78689cds_at | |
A_42_P498708 | |
286993_Rn | |
98376_at | |
161119_at | |
98377_at | |
98378_g_at | |
1420557_at | |
U07357_s_at | |
Msa.204.0_at | |
A_51_P128174 | |
NM_007937 | |
AF101726 | |
216837_at | |
215664_s_at | |
238241_at | |
34564_at | |
80453_at | |
1605_g_at | |
L36644_at | |
X95425_s_at | |
1604_AT | |
A_23_P147834 | |
I_1152288 | |
A_23_P72340 | |
I_1000650 |
State | ephrin receptor isoform a |
---|---|
ephrin receptor isoform b |
State Description | Transcript Variant: This variant (1) encodes the longer isoform (a). |
---|---|
Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter C-terminus. |
MGI ID | 99654 |
---|
GO Molecular Function | ephrin receptor activity |
---|---|
protein-tyrosine kinase activity | |
ATP binding | |
protein serine/threonine kinase activity | |
receptor activity | |
protein kinase activity | |
kinase activity | |
transferase activity | |
transmembrane-ephrin receptor activity |
GO ID | GO:0005003 |
---|---|
GO:0004713 | |
GO:0005524 | |
GO:0004674 | |
GO:0004872 | |
GO:0004672 | |
GO:0016301 | |
GO:0016740 | |
GO:0007169 | |
GO:0006468 | |
GO:0016020 | |
GO:0016021 | |
GO:0005005 |
Swiss-Prot Accession | P54756 |
---|
Keyword | receptor protein tyrosine kinase |
---|
OMIM ID | OMIM:600004 |
---|
Alias | Els1 |
---|---|
eck-like sequence 1 | |
Epha5 | |
bsk | |
Cek7 | |
Ehk1 | |
Hek7 | |
Rek7 | |
Els | |
Eph receptor A5 | |
Eph homology kinase-1 | |
ephrin type-A receptor 5 | |
receptor protein-tyrosine kinase HEK7 | |
tyrosine-protein kinase receptor EHK-1 | |
AI854630 | |
eck-like sequence I | |
EHK I | |
Els I | |
Eph homology kinase I | |
ephrin receptor EphA5 | |
Ephrin type-A receptor V | |
expressed sequence AI854630 | |
Receptor protein- tyrosine kinase HEK7 | |
similar to receptor tyrosine kinase Ehk I | |
similar to receptor tyrosine kinase Ehk-1 | |
TYRO4 | |
TYRO4 protein tyrosine kinase | |
Tyrosine-protein kinase receptor EHK I | |
Tyrosine-protein kinase receptor EHK-1 | |
similar to receptor tyrosine kinase Ehk-1 - rat |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 79208 |
---|---|
13718 | |
13839 | |
100769 | |
2044 | |
7304 |
Source | ResNet |
---|
RGD ID | 620831 |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.24569 |
---|---|
Mm.137991 | |
Hs.201920 | |
Mm.4466 |
Group | nucleotide binding |
---|