Protein : EPHA5

Connectivity 14
Notes This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
Hugo ID 3389
Name EPHA5
Description EphA5
URN urn:agi-llid:2044

GO Cellular Component integral to membrane
membrane

Cell Localization Plasma membrane

GO Biological Process protein amino acid phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway

EC Number 2.7.1.112

Microarray ID 1371007_at
rc_AI231376_at
X78689cds_at
A_42_P498708
286993_Rn
98376_at
161119_at
98377_at
98378_g_at
1420557_at
U07357_s_at
Msa.204.0_at
A_51_P128174
NM_007937
AF101726
216837_at
215664_s_at
238241_at
34564_at
80453_at
1605_g_at
L36644_at
X95425_s_at
1604_AT
A_23_P147834
I_1152288
A_23_P72340
I_1000650

GenBank ID NW_047424
XM_341201
XP_341202
X78689
CAA55357
U07357
NT_039307
NM_007937
NP_031963
BC057401
AAH57401
AAA17038
X69674
CAA49355
Q60629
BX537946
L36644
X95425
NT_022778
NM_004439
NP_004430
NM_182472
NP_872272
CAD97914
AAA74245
P54756
AF101726

State ephrin receptor isoform a
ephrin receptor isoform b

State Description Transcript Variant: This variant (1) encodes the longer isoform (a).
Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter C-terminus.

MGI ID 99654

GO Molecular Function ephrin receptor activity
protein-tyrosine kinase activity
ATP binding
protein serine/threonine kinase activity
receptor activity
protein kinase activity
kinase activity
transferase activity
transmembrane-ephrin receptor activity

GO ID GO:0005003
GO:0004713
GO:0005524
GO:0004674
GO:0004872
GO:0004672
GO:0016301
GO:0016740
GO:0007169
GO:0006468
GO:0016020
GO:0016021
GO:0005005

Swiss-Prot Accession P54756

Keyword receptor protein tyrosine kinase

OMIM ID OMIM:600004

Alias Els1
eck-like sequence 1
Epha5
bsk
Cek7
Ehk1
Hek7
Rek7
Els
Eph receptor A5
Eph homology kinase-1
ephrin type-A receptor 5
receptor protein-tyrosine kinase HEK7
tyrosine-protein kinase receptor EHK-1
AI854630
eck-like sequence I
EHK I
Els I
Eph homology kinase I
ephrin receptor EphA5
Ephrin type-A receptor V
expressed sequence AI854630
Receptor protein- tyrosine kinase HEK7
similar to receptor tyrosine kinase Ehk I
similar to receptor tyrosine kinase Ehk-1
TYRO4
TYRO4 protein tyrosine kinase
Tyrosine-protein kinase receptor EHK I
Tyrosine-protein kinase receptor EHK-1
similar to receptor tyrosine kinase Ehk-1 - rat

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 79208
13718
13839
100769
2044
7304

Source ResNet

RGD ID 620831

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.24569
Mm.137991
Hs.201920
Mm.4466

Group nucleotide binding