Protein : GPHN

Connectivity 29
Notes To integrate signals from the many synaptic connections on its cell body and dendrites rapidly and specifically, a neuron anchors high concentrations of receptors at postsynaptic sites, matching the correct receptor with the neurotransmitter released from the presynaptic terminal. Receptor-associated proteins are thought to be involved in forming these postsynaptic specializations, possibly by linking the receptor to the postsynaptic cytoskeleton. Gephyrin is essential for both the postsynaptic localization of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor in different peripheral organs.[supplied by OMIM]
Hugo ID 15465
Name GPHN
Description gephyrin
URN urn:agi-llid:10243

GO Cellular Component cytoskeleton
extrinsic to plasma membrane

Cell Localization Plasma membrane
Cytoplasm

GO Biological Process Mo-molybdopterin cofactor biosynthesis
establishment of synaptic specificity at neuromuscular junction
protein targeting

Microarray ID 1368117_at
X66366_at
99441_at
1426462_at
1426463_at
aa624733_at
aa624733_g_at
Msa.10435.0_s_at
Msa.10435.0_at
msa.11262.0_s_at
A_51_P210293
AK082353
A_65_P05510
H3001A11-3
234941_s_at
65178_at
220773_s_at
223319_at
T83389_at
A_23_P88141
I_959469
A_32_P874881
I_3227133

GenBank ID X66366
NW_047761
XM_346771
XP_346772
CAA47009
NP_074056
AK082353
NT_039551
NM_172952
NP_766540
Y10882
AJ278768
CAC06105
AJ278769
CAC06106
AJ278770
CAC06107
BAC38476
BC027112
AAH27112
Y10883
BC030016
NT_026437
NM_020806
NP_065857
AB037806
BAA92623
AF272663
AAF81785
AJ272033
CAC81240
AJ272343
CAC10537
AK025169
AAH30016
Q9NQX3

MGI ID 109602

GO Molecular Function cytoskeletal protein binding
catalytic activity

GO ID GO:0008092
GO:0003824
GO:0006777
GO:0006605
GO:0007529
GO:0005856
GO:0019897

Swiss-Prot Accession Q9NQX3

OMIM ID OMIM:603930
OMIM:252150

Alias Gphn
Geph
gephyrin
5730552E08Rik
RIKEN cDNA 5730552E08 gene
GPH
GPHRYN
MGC38765
C230040D23
gephryin
KIAA1385

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 64845
14750
70669
104874
211635
217680
268566
10243
57566

Source ResNet

RGD ID 69194

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.11032
Mm.40282
Hs.13405