Connectivity | 29 |
---|---|
Notes | To integrate signals from the many synaptic connections on its cell body and dendrites rapidly and specifically, a neuron anchors high concentrations of receptors at postsynaptic sites, matching the correct receptor with the neurotransmitter released from the presynaptic terminal. Receptor-associated proteins are thought to be involved in forming these postsynaptic specializations, possibly by linking the receptor to the postsynaptic cytoskeleton. Gephyrin is essential for both the postsynaptic localization of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor in different peripheral organs.[supplied by OMIM] |
Hugo ID | 15465 |
Name | GPHN |
Description | gephyrin |
URN | urn:agi-llid:10243 |
GO Cellular Component | cytoskeleton |
---|---|
extrinsic to plasma membrane |
Cell Localization | Plasma membrane |
---|---|
Cytoplasm |
GO Biological Process | Mo-molybdopterin cofactor biosynthesis |
---|---|
establishment of synaptic specificity at neuromuscular junction | |
protein targeting |
Microarray ID | 1368117_at |
---|---|
X66366_at | |
99441_at | |
1426462_at | |
1426463_at | |
aa624733_at | |
aa624733_g_at | |
Msa.10435.0_s_at | |
Msa.10435.0_at | |
msa.11262.0_s_at | |
A_51_P210293 | |
AK082353 | |
A_65_P05510 | |
H3001A11-3 | |
234941_s_at | |
65178_at | |
220773_s_at | |
223319_at | |
T83389_at | |
A_23_P88141 | |
I_959469 | |
A_32_P874881 | |
I_3227133 |
MGI ID | 109602 |
---|
GO Molecular Function | cytoskeletal protein binding |
---|---|
catalytic activity |
GO ID | GO:0008092 |
---|---|
GO:0003824 | |
GO:0006777 | |
GO:0006605 | |
GO:0007529 | |
GO:0005856 | |
GO:0019897 |
Swiss-Prot Accession | Q9NQX3 |
---|
OMIM ID | OMIM:603930 |
---|---|
OMIM:252150 |
Alias | Gphn |
---|---|
Geph | |
gephyrin | |
5730552E08Rik | |
RIKEN cDNA 5730552E08 gene | |
GPH | |
GPHRYN | |
MGC38765 | |
C230040D23 | |
gephryin | |
KIAA1385 |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 64845 |
---|---|
14750 | |
70669 | |
104874 | |
211635 | |
217680 | |
268566 | |
10243 | |
57566 |
Source | ResNet |
---|
RGD ID | 69194 |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.11032 |
---|---|
Mm.40282 | |
Hs.13405 |