Connectivity | 46 |
---|---|
Notes | This gene encodes a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity and may be important for learning and memory. It also may be involved in the transmission of light information from the retina to the hypothalamus. The structure and function of the encoded protein is changed by RNA editing. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. |
Hugo ID | 4580 |
Name | GRIK2 |
Description | glutamate receptor, ionotropic, kainate 2 |
URN | urn:agi-llid:2898 |
GO Cellular Component | integral to membrane |
---|---|
membrane | |
extracellular space | |
ionotropic glutamate receptor complex | |
integral to plasma membrane |
Cell Localization | Plasma membrane |
---|
GO Biological Process | ion transport |
---|---|
potassium ion transport | |
synaptic transmission | |
transport | |
glutamate signaling pathway |
State | glutamate receptor 6 isoform 1 precursor |
---|---|
glutamate receptor 6 isoform 2 precursor |
State Description | Transcript Variant: This variant (1) encodes the longer isoform (1). |
---|---|
Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. |
MGI ID | 95815 |
---|
Swiss-Prot Accession | Q13002 |
---|
OMIM ID | OMIM:138244 |
---|
Alias | Grik2 |
---|---|
GluR6 | |
glutamate receptor, ionotropic, kainate 2 | |
glutamate receptor 6 | |
Glur-6 | |
AW124492 | |
glutamate receptor, ionotropic, kainate 2 (beta 2) | |
expressed sequence AW124492 | |
EAA4 | |
excitatory amino acid receptor 4 | |
Excitatory amino acid receptor IV | |
Glutamate receptor 6 | |
Glutamate receptor VI | |
Glutamate receptor, ionotropic kainate 2 precursor | |
similar to Glu receptor |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 54257 |
---|---|
14806 | |
103430 | |
2898 |
RGD ID | 2733 |
---|
Pathway | Copy of 'path8' |
---|---|
path8 | |
pathfeb |
Unigene ID | Rn.87696 |
---|---|
Mm.40190 | |
Hs.307494 |
Group | Receptors |
---|---|
New Group |