Connectivity | 737 |
---|---|
Notes | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
Hugo ID | 620 |
Name | APP |
Description | amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) |
URN | urn:agi-llid:351 |
GO Cellular Component | coated pit |
---|---|
integral to membrane | |
membrane | |
Golgi apparatus | |
endoplasmic reticulum | |
extracellular | |
integral to plasma membrane |
Cell Localization | Plasma membrane |
---|---|
Cytoplasm | |
Golgi |
GO Biological Process | apoptosis |
---|---|
cell adhesion | |
endocytosis | |
induction of apoptosis | |
cell death | |
copper ion homeostasis | |
signal transduction |
Microarray ID | 1371571_at |
---|---|
1371572_at | |
rc_AA956735_at | |
rc_AA819527_at | |
rc_AI178039_at | |
1380533_at | |
1420621_a_at | |
93063_at | |
1427442_a_at | |
x59379_s_at | |
Msa.389.0_at | |
msa.10643.0_s_at | |
msa.27234.0_s_at | |
A_51_P318104 | |
NM_007471 | |
A_65_P01999 | |
L0063B06-3 | |
Y00264 | |
214953_s_at | |
41136_s_at | |
64309_f_at | |
70660_at | |
200602_at | |
211277_x_at | |
212412_at | |
W27334_at | |
RC_AA128553_f_at | |
RC_H88303_s_at | |
Y00264_at | |
37182_AT | |
37326_AT | |
A_23_P6216 | |
I_962152 | |
1434427_a_at | |
1438373_at | |
1438374_x_at | |
1454953_at | |
1456741_s_at |
State | amyloid beta A4 protein precursor, isoform a |
---|---|
amyloid beta A4 protein precursor, isoform b | |
amyloid beta A4 protein precursor, isoform c |
State Description | Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). |
---|---|
Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. | |
Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. |
MGI ID | 88059 |
---|
GO Molecular Function | heparin binding |
---|---|
serine protease inhibitor activity | |
cell adhesion molecule activity | |
protein binding | |
structural molecule activity | |
heparin binding activity | |
protein binding activity |
GO ID | GO:0008201 |
---|---|
GO:0004867 | |
GO:0005194 | |
GO:0006897 | |
GO:0007155 | |
GO:0006915 | |
GO:0005905 | |
GO:0016020 | |
GO:0016021 | |
GO:0005515 | |
GO:0005198 | |
GO:0006878 | |
GO:0008219 | |
GO:0007165 | |
GO:0005794 | |
GO:0005576 | |
GO:0005783 | |
GO:0005887 |
Swiss-Prot Accession | P05067 |
---|
Keyword | plasma membrane |
---|---|
collagen | |
secretase | |
amyloid protein |
OMIM ID | OMIM:104760 |
---|
Alias | App |
---|---|
A4_RAT | |
amyloid beta (A4) precursor protein | |
Amyloidogenic glycoprotein | |
Adap | |
Cvap | |
Abeta | |
appican | |
betaAPP | |
protease nexin II | |
AAA | |
AD1 | |
PN2 | |
ABPP | |
APPI | |
PreA4 | |
A4 | |
amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) | |
Alzheimer disease 1 | |
amyloid beta-peptide | |
cerebral vascular amyloid peptide | |
amyloid of aging and Alzheimer disease | |
A4_HUMAN | |
Alzheimer s disease amyloid beta protein precursor | |
Abeta1-40 | |
Abeta1-42 | |
Abeta2-42 | |
Abeta42 | |
AbetaPP | |
AID 50 | |
AID 57 | |
AID 59 | |
Alzheimer's disease amyloid A4 protein precursor | |
Alzheimer's disease amyloid protein | |
amyloid betaprotein | |
Amyloid intracellular domain 50 | |
Amyloid intracellular domain 57 | |
Amyloid intracellular domain 59 | |
amyloid-beta peptide (1-40) | |
amyloid-beta(1-40) | |
APP-alpha | |
APP-beta | |
beta amyloid protein | |
beta amyloid protein 40 | |
beta amyloid protein 42 | |
beta-APP40 | |
beta-APP42 | |
Gamma-CTF 50 | |
Gamma-CTF 57 | |
Gamma-CTF 59 | |
Gamma-secretase C-terminal fragment 50 | |
Gamma-secretase C-terminal fragment 57 | |
Gamma-secretase C-terminal fragment 59 | |
human mRNA for amyloid A4 precursor of Alzheimer's disease | |
P3(40) | |
P3(42) | |
PN-II | |
Protease nexin-II | |
S-APP-alpha | |
S-APP-beta | |
Alzheimer s disease amyloid | |
amyloid beta (A4) (protease nexin-II, Alzheimer disease) | |
amyloid beta (A4) precursor protein (Alzheimer disease) |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 54226 |
---|---|
11820 | |
106302 | |
351 |
Source | ResNet |
---|
RGD ID | 2139 |
---|
Pathway | Caspases |
---|---|
Apoptosis | |
path | |
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.2104 |
---|---|
Mm.277585 | |
Hs.177486 | |
Mm.265956 | |
Mm.131766 | |
Mm.15571 |
Group | protein binding |
---|---|
glycosaminoglycan binding |