Protein : APP

Connectivity 737
Notes This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Hugo ID 620
Name APP
Description amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)
URN urn:agi-llid:351

GO Cellular Component coated pit
integral to membrane
membrane
Golgi apparatus
endoplasmic reticulum
extracellular
integral to plasma membrane

Cell Localization Plasma membrane
Cytoplasm
Golgi

GO Biological Process apoptosis
cell adhesion
endocytosis
induction of apoptosis
cell death
copper ion homeostasis
signal transduction

Microarray ID 1371571_at
1371572_at
rc_AA956735_at
rc_AA819527_at
rc_AI178039_at
1380533_at
1420621_a_at
93063_at
1427442_a_at
x59379_s_at
Msa.389.0_at
msa.10643.0_s_at
msa.27234.0_s_at
A_51_P318104
NM_007471
A_65_P01999
L0063B06-3
Y00264
214953_s_at
41136_s_at
64309_f_at
70660_at
200602_at
211277_x_at
212412_at
W27334_at
RC_AA128553_f_at
RC_H88303_s_at
Y00264_at
37182_AT
37326_AT
A_23_P6216
I_962152
1434427_a_at
1438373_at
1438374_x_at
1454953_at
1456741_s_at

GenBank ID AF513015
NW_047354
NM_019288
NP_062161
AY011335
AAG47370
L11926
AAA74458
AAM90259
BC062082
AAH62082
M18373
NT_039625
NM_007471
NP_031497
D10603
BAA01456
U82624
AAB40919
AK052448
BAC34997
AK076506
BAC36369
AK128971
AY267348
AAP23169
BC005490
AAH05490
AAA37139
M24397
AAA39929
U84012
AAB41502
X15210
CAA33280
X59379
P12023
AH005295
NT_011512
NM_000484
NP_000475
D87675
BAA22264
M24546
AAC13654
M33112
AAB59502
M34862
M34863
M34864
M34865
M34866
M34867
M34868
M34869
M34870
M34871
M34872
M34873
M34874
M34875
AAB59501
M34876
M34877
M34878
M34879
AF282245
AAQ14327
BC004369
AAH04369
BC018937
M15532
AAA51564
M15533
AAA35540
M16765
AAA51722
M18734
AAA51726
M28373
AAA58727
X06989
CAA30050
Y00264
CAA68374
P05067
NW_042746
XM_213671
XP_213671

State amyloid beta A4 protein precursor, isoform a
amyloid beta A4 protein precursor, isoform b
amyloid beta A4 protein precursor, isoform c

State Description Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

MGI ID 88059

GO Molecular Function heparin binding
serine protease inhibitor activity
cell adhesion molecule activity
protein binding
structural molecule activity
heparin binding activity
protein binding activity

GO ID GO:0008201
GO:0004867
GO:0005194
GO:0006897
GO:0007155
GO:0006915
GO:0005905
GO:0016020
GO:0016021
GO:0005515
GO:0005198
GO:0006878
GO:0008219
GO:0007165
GO:0005794
GO:0005576
GO:0005783
GO:0005887

Swiss-Prot Accession P05067

Keyword plasma membrane
collagen
secretase
amyloid protein

OMIM ID OMIM:104760

Alias App
A4_RAT
amyloid beta (A4) precursor protein
Amyloidogenic glycoprotein
Adap
Cvap
Abeta
appican
betaAPP
protease nexin II
AAA
AD1
PN2
ABPP
APPI
PreA4
A4
amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease)
Alzheimer disease 1
amyloid beta-peptide
cerebral vascular amyloid peptide
amyloid of aging and Alzheimer disease
A4_HUMAN
Alzheimer s disease amyloid beta protein precursor
Abeta1-40
Abeta1-42
Abeta2-42
Abeta42
AbetaPP
AID 50
AID 57
AID 59
Alzheimer's disease amyloid A4 protein precursor
Alzheimer's disease amyloid protein
amyloid betaprotein
Amyloid intracellular domain 50
Amyloid intracellular domain 57
Amyloid intracellular domain 59
amyloid-beta peptide (1-40)
amyloid-beta(1-40)
APP-alpha
APP-beta
beta amyloid protein
beta amyloid protein 40
beta amyloid protein 42
beta-APP40
beta-APP42
Gamma-CTF 50
Gamma-CTF 57
Gamma-CTF 59
Gamma-secretase C-terminal fragment 50
Gamma-secretase C-terminal fragment 57
Gamma-secretase C-terminal fragment 59
human mRNA for amyloid A4 precursor of Alzheimer's disease
P3(40)
P3(42)
PN-II
Protease nexin-II
S-APP-alpha
S-APP-beta
Alzheimer s disease amyloid
amyloid beta (A4) (protease nexin-II, Alzheimer disease)
amyloid beta (A4) precursor protein (Alzheimer disease)

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 54226
11820
106302
351

Source ResNet

RGD ID 2139

Pathway Caspases
Apoptosis
path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.2104
Mm.277585
Hs.177486
Mm.265956
Mm.131766
Mm.15571

Group protein binding
glycosaminoglycan binding