Protein : MAPK9


Connectivity	258
Notes	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggested a key role in T differentiation.
Hugo ID	6886
Name	MAPK9
Description	mitogen-activated protein kinase 9
URN	urn:agi-llid:5601


GO Cellular Component	nucleus


Cell Localization	Nucleus
	Cytoplasm


GO Biological Process	JNK cascade
	protein amino acid phosphorylation
	response to stress
	signal transduction


EC Number	2.7.1.-
	2.7.1.37


State Description	Transcript Variant: This variant (2) lacks an alternate coding exon and contains another compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
	Transcript Variant: This variant (1) encodes the longer isoform (a).
	Transcript Variant: This variant (1), also known as JNK2 alpha1, encodes the longest isoform (1).
	Transcript Variant: This variant (2), also known as JNK2 alpha2, contains an extra coding region segment when compared to variant 1. The resulting isoform (2) is frameshifted and has a distinct C-terminus compared to isoform 1.
	Transcript Variant: This variant (3), also known as JNK2 beta1, contains two different coding segments when compared to variant 1. The second extra segment causes a frameshift with the resulting isoform (3) containing a distinct, shorter C-terminus, an...
	Transcript Variant: This variant (4), also known as JNK2 beta2, contains a different coding segment when compared to variant 1. The resulting isoform (4) maintains the same reading frame with a different internal region as compared to isoform 1.


MGI ID	1346862


GO Molecular Function	JUN kinase activity
	MAP kinase activity
	cAMP-dependent protein kinase activity
	protein kinase CK2 activity
	ATP binding
	protein serine/threonine kinase activity
	protein kinase activity
	transferase activity
	protein-tyrosine kinase activity
	NOT protein binding
	protein binding activity


Swiss-Prot Accession	P45984


Keyword	RNA


OMIM ID	OMIM:602896


Alias	Mapk9
	SAPK
	stress activated protein kinase alpha II
	JNK2
	Prkm9
	MAPK9.
	mitogen activated protein kinase 9
	Jun kinase
	JNK/SAPK alpha
	protein kinase, mitogen-activated 9
	p54aSAPK
	JNK2A
	JNK2B
	JNK-55
	MK09
	mitogen-activated protein kinase 9
	MAP kinase 9
	c-Jun kinase 2
	c-Jun N-terminal kinase 2
	stress-activated protein kinase JNK2
	MK09_HUMAN
	protein kinase JNK2
	JNK2BETA
	JNK2ALPHA
	c-Jun kinase II
	c-Jun N-terminal kinase II
	protein kinase mitogen-activated 9 (MAP kinase)
	Stress-activated protein kinase JNK2
	JNK/SAPK


Source	ResNet


RGD ID	628847


Group	nucleotide binding