Connectivity | 120 |
---|---|
Notes | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation. |
Hugo ID | 4571 |
Name | GRIA1 |
Description | glutamate receptor, ionotropic, AMPA 1 |
URN | urn:agi-llid:2890 |
GO Cellular Component | integral to membrane |
---|---|
membrane | |
extracellular space | |
plasma membrane |
Cell Localization | Plasma membrane |
---|---|
Cytoplasm |
GO Biological Process | ion transport |
---|---|
learning and/or memory | |
potassium ion transport | |
regulation of long-term neuronal synaptic plasticity | |
synaptic transmission | |
transport | |
protein amino acid prenylation | |
signal transduction |
Microarray ID | 1371013_at |
---|---|
X17184_at | |
M36418_s_at | |
A_43_P15761 | |
X17184.1 | |
92943_at | |
92944_at | |
1448972_at | |
X57497_s_at | |
Msa.2313.0_at | |
1425700_at | |
A_51_P498031 | |
NM_008165 | |
A_65_P01960 | |
L0854H08-3 | |
A_65_P02018 | |
L0841F12-3 | |
M64752 | |
36855_r_at | |
36854_s_at | |
36853_at | |
211520_s_at | |
209793_at | |
M81886_s_at | |
RC_T23452_s_at | |
M64752_at | |
A_23_P144939 | |
I_962792 | |
A_23_P303072 | |
NM_000827.2 | |
A_32_P374496 | |
I_3316105 |
MGI ID | 95808 |
---|
GO Molecular Function | glutamate-gated ion channel activity |
---|---|
ion channel activity | |
potassium channel activity | |
transporter activity | |
inotropic glutamate receptor activity | |
receptor activity | |
protein prenyltransferase activity | |
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity | |
kainate selective glutamate receptor activity |
GO ID | GO:0005234 |
---|---|
GO:0005216 | |
GO:0005267 | |
GO:0005215 | |
GO:0004970 | |
GO:0004872 | |
GO:0006813 | |
GO:0006810 | |
GO:0006811 | |
GO:0007268 | |
GO:0016020 | |
GO:0016021 | |
GO:0008318 | |
GO:0018346 | |
GO:0005615 | |
GO:0004971 | |
GO:0015277 | |
GO:0007165 | |
GO:0005886 |
Swiss-Prot Accession | P42261 |
---|
Keyword | glutamate receptor |
---|
OMIM ID | OMIM:138248 |
---|
Alias | Gria1 |
---|---|
glutamate receptor, ionotropic, AMPA1 (alpha 1) | |
Glr1 | |
Glr-1 | |
GluRA | |
Glur1 | |
HIPA1 | |
GluR-A | |
Glur-1 | |
glutamate receptor 1 | |
2900051M01Rik | |
Glr I | |
GLUH1 | |
HBGR1 | |
AMPA1 | |
glutamate receptor, ionotropic, AMPA 1 | |
AMPA 1 | |
AMPA I | |
GLUH I | |
GLUR I | |
GLUR-K I | |
GLUR-K1 | |
Glutamate receptor ionotropic, AMPA 1 | |
Glutamate receptor ionotropic, AMPA I | |
Glutamate receptor 1 precursor | |
Gria I | |
HBGR I | |
RIKEN cDNA 2900051M01 gene | |
glutamate receptor, ionotropic, AMPA |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 50592 |
---|---|
14653 | |
14799 | |
72995 | |
103876 | |
109802 | |
2890 |
Source | ResNet |
---|
RGD ID | 621531 |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.29971 |
---|---|
Mm.4920 | |
Hs.7117 |
Group | Receptors |
---|