Protein : GRIA1

Connectivity 120
Notes Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.
Hugo ID 4571
Name GRIA1
Description glutamate receptor, ionotropic, AMPA 1
URN urn:agi-llid:2890

GO Cellular Component integral to membrane
membrane
extracellular space
plasma membrane

Cell Localization Plasma membrane
Cytoplasm

GO Biological Process ion transport
learning and/or memory
potassium ion transport
regulation of long-term neuronal synaptic plasticity
synaptic transmission
transport
protein amino acid prenylation
signal transduction

Microarray ID 1371013_at
X17184_at
M36418_s_at
A_43_P15761
X17184.1
92943_at
92944_at
1448972_at
X57497_s_at
Msa.2313.0_at
1425700_at
A_51_P498031
NM_008165
A_65_P01960
L0854H08-3
A_65_P02018
L0841F12-3
M64752
36855_r_at
36854_s_at
36853_at
211520_s_at
209793_at
M81886_s_at
RC_T23452_s_at
M64752_at
A_23_P144939
I_962792
A_23_P303072
NM_000827.2
A_32_P374496
I_3316105

GenBank ID X17184
M36418
AAA41243
M38060
AAA63479
CAA35050
NP_113796
BC056397
NT_039515
NM_008165
NP_032191
AK013661
AK013839
BAB29014
AK049958
AAH56397
BC060702
AAH60702
X57497
CAA40734
P23818
M64752
M81886
NT_029289
NM_000827
NP_000818
AAA58613
AAA58395
X58633
CAA41491
P42261

MGI ID 95808

GO Molecular Function glutamate-gated ion channel activity
ion channel activity
potassium channel activity
transporter activity
inotropic glutamate receptor activity
receptor activity
protein prenyltransferase activity
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
kainate selective glutamate receptor activity

GO ID GO:0005234
GO:0005216
GO:0005267
GO:0005215
GO:0004970
GO:0004872
GO:0006813
GO:0006810
GO:0006811
GO:0007268
GO:0016020
GO:0016021
GO:0008318
GO:0018346
GO:0005615
GO:0004971
GO:0015277
GO:0007165
GO:0005886

Swiss-Prot Accession P42261

Keyword glutamate receptor

OMIM ID OMIM:138248

Alias Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
Glr1
Glr-1
GluRA
Glur1
HIPA1
GluR-A
Glur-1
glutamate receptor 1
2900051M01Rik
Glr I
GLUH1
HBGR1
AMPA1
glutamate receptor, ionotropic, AMPA 1
AMPA 1
AMPA I
GLUH I
GLUR I
GLUR-K I
GLUR-K1
Glutamate receptor ionotropic, AMPA 1
Glutamate receptor ionotropic, AMPA I
Glutamate receptor 1 precursor
Gria I
HBGR I
RIKEN cDNA 2900051M01 gene
glutamate receptor, ionotropic, AMPA

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 50592
14653
14799
72995
103876
109802
2890

Source ResNet

RGD ID 621531

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.29971
Mm.4920
Hs.7117

Group Receptors