Protein : PTPRF

Connectivity 110
Notes The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Hugo ID 9670
Name PTPRF
Description protein tyrosine phosphatase, receptor type, F
URN urn:agi-llid:5792

GO Cellular Component extracellular space
integral to membrane
integral to plasma membrane
plasma membrane
nucleus

Cell Localization Plasma membrane

GO Biological Process homophilic cell adhesion
neurogenesis
cell adhesion
protein amino acid dephosphorylation
transmembrane receptor protein tyrosine phosphatase signaling pathway

EC Number 3.1.3.48

Microarray ID 1368035_a_at
1368036_at
M60103_at
X83546_at
1371086_at
96272_at
1420841_at
1420842_at
1420843_at
109849_f_at
165261_i_at
aa048018_s_at
Msa.16718.0_s_at
Msa.23615.0_s_at
Msa.16718.0_at
Msa.23615.0_at
Msa.43192.0_at
Msa.43192.0_g_at
msa.11743.0_at
msa.30154.0_s_at
A_51_P466478
NM_011213
A_65_P08637
L0031B05-3
A_65_P14341
L0265C11-3
Y00815
200635_s_at
200637_s_at
36204_at
200636_s_at
Y00815_at
1264_AT
1265_G_AT
A_32_P416233
I_2016274
A_23_P200989
I_931679

GenBank ID L11586
NW_047559
XM_346987
XP_346988
AAC37655
M60103
AAA41510
U00477
AAC04306
X83505
CAA58495
X83546
CAA58537
NP_062122
AF300943
NT_039264
NM_011213
NP_035343
AAG40194
BC057166
AAH57166
Z23049
CAA80584
Z23061
CAA80596
Z37988
CAA86070
BI711143
Y00815
NT_032977
NM_002840
NP_002831
NM_130440
NP_569707
BC012102
AAH12102
BC029466
BC048416
AAH48416
BC048768
AAH48768
BX537361
CAD97607
CAA68754
P10586
AK023775

State isoform 1 precursor
isoform 2 precursor

State Description Transcript Variant: This variant (1) contains an extra internal fragment within the coding region when compared to variant 2. It thus encodes a protein that has a 9 aa internal fragment absent in isoform 2.
Transcript Variant: This variant (2) lacks an internal fragment within the coding region when compared to variant 1. It thus encodes a protein that lacks a 9 aa internal fragment present in isoform 1.

MGI ID 102695

GO Molecular Function transmembrane receptor protein tyrosine phosphatase activity
protein phosphatase activity
receptor activity
cell adhesion molecule activity
protein tyrosine phosphatase activity
prenylated protein tyrosine phosphatase activity
hydrolase activity

GO ID GO:0005001
GO:0004721
GO:0004872
GO:0005194
GO:0004725
GO:0004727
GO:0016787
GO:0007185
GO:0007155
GO:0006470
GO:0016021
GO:0005887
GO:0005615
GO:0005886

Swiss-Prot Accession P10586

Keyword protein-tyrosine phosphatase
3.1.3.48

OMIM ID OMIM:179590

Alias Ptprf
LARFN5C
protein tyrosine phosphatase, receptor type, F
leukocyte antigen-related (LAR) PTP receptor
protein tyrosine phosphatase receptor-type F
protein tyrosine phosphatase, receptor-type, F
LAR
LARS
LCA-homolog
leukocyte antigen-related tyrosine phosphatase
receptor-linked protein-tyrosine phosphatase LAR
protein tyrosine phosphatase, receptor type, F polypeptide
LAR protein precursor
Leukocyte antigen related

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 29615
19268
100011
5792

Source ResNet

RGD ID 3453

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.11386
Mm.29855
Hs.75216

Group Receptors
protein binding
nucleic acid binding
New Group