Connectivity | 110 |
---|---|
Notes | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
Hugo ID | 9670 |
Name | PTPRF |
Description | protein tyrosine phosphatase, receptor type, F |
URN | urn:agi-llid:5792 |
GO Cellular Component | extracellular space |
---|---|
integral to membrane | |
integral to plasma membrane | |
plasma membrane | |
nucleus |
Cell Localization | Plasma membrane |
---|
GO Biological Process | homophilic cell adhesion |
---|---|
neurogenesis | |
cell adhesion | |
protein amino acid dephosphorylation | |
transmembrane receptor protein tyrosine phosphatase signaling pathway |
EC Number | 3.1.3.48 |
---|
Microarray ID | 1368035_a_at |
---|---|
1368036_at | |
M60103_at | |
X83546_at | |
1371086_at | |
96272_at | |
1420841_at | |
1420842_at | |
1420843_at | |
109849_f_at | |
165261_i_at | |
aa048018_s_at | |
Msa.16718.0_s_at | |
Msa.23615.0_s_at | |
Msa.16718.0_at | |
Msa.23615.0_at | |
Msa.43192.0_at | |
Msa.43192.0_g_at | |
msa.11743.0_at | |
msa.30154.0_s_at | |
A_51_P466478 | |
NM_011213 | |
A_65_P08637 | |
L0031B05-3 | |
A_65_P14341 | |
L0265C11-3 | |
Y00815 | |
200635_s_at | |
200637_s_at | |
36204_at | |
200636_s_at | |
Y00815_at | |
1264_AT | |
1265_G_AT | |
A_32_P416233 | |
I_2016274 | |
A_23_P200989 | |
I_931679 |
State | isoform 1 precursor |
---|---|
isoform 2 precursor |
State Description | Transcript Variant: This variant (1) contains an extra internal fragment within the coding region when compared to variant 2. It thus encodes a protein that has a 9 aa internal fragment absent in isoform 2. |
---|---|
Transcript Variant: This variant (2) lacks an internal fragment within the coding region when compared to variant 1. It thus encodes a protein that lacks a 9 aa internal fragment present in isoform 1. |
MGI ID | 102695 |
---|
GO Molecular Function | transmembrane receptor protein tyrosine phosphatase activity |
---|---|
protein phosphatase activity | |
receptor activity | |
cell adhesion molecule activity | |
protein tyrosine phosphatase activity | |
prenylated protein tyrosine phosphatase activity | |
hydrolase activity |
GO ID | GO:0005001 |
---|---|
GO:0004721 | |
GO:0004872 | |
GO:0005194 | |
GO:0004725 | |
GO:0004727 | |
GO:0016787 | |
GO:0007185 | |
GO:0007155 | |
GO:0006470 | |
GO:0016021 | |
GO:0005887 | |
GO:0005615 | |
GO:0005886 |
Swiss-Prot Accession | P10586 |
---|
Keyword | protein-tyrosine phosphatase |
---|---|
3.1.3.48 |
OMIM ID | OMIM:179590 |
---|
Alias | Ptprf |
---|---|
LARFN5C | |
protein tyrosine phosphatase, receptor type, F | |
leukocyte antigen-related (LAR) PTP receptor | |
protein tyrosine phosphatase receptor-type F | |
protein tyrosine phosphatase, receptor-type, F | |
LAR | |
LARS | |
LCA-homolog | |
leukocyte antigen-related tyrosine phosphatase | |
receptor-linked protein-tyrosine phosphatase LAR | |
protein tyrosine phosphatase, receptor type, F polypeptide | |
LAR protein precursor | |
Leukocyte antigen related |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 29615 |
---|---|
19268 | |
100011 | |
5792 |
Source | ResNet |
---|
RGD ID | 3453 |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.11386 |
---|---|
Mm.29855 | |
Hs.75216 |
Group | Receptors |
---|---|
protein binding | |
nucleic acid binding | |
New Group |