Connectivity | 8 |
---|---|
Notes | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors respond by undergoing an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The protein encoded by this gene is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene appear to account for a small proportion of the cases of nocturnal frontal lobe epilepsy. |
Hugo ID | 1958 |
Name | CHRNA4 |
Description | cholinergic receptor, nicotinic, alpha polypeptide 4 |
URN | urn:agi-llid:1137 |
GO Cellular Component | integral to membrane |
---|---|
membrane | |
nicotinic acetylcholine-gated receptor-channel complex | |
membrane fraction | |
postsynaptic membrane |
Cell Localization | Plasma membrane |
---|---|
Cytoplasm |
GO Biological Process | ion transport |
---|---|
synaptic transmission | |
transport | |
behavior | |
sensory perception | |
synaptic transmission, cholinergic | |
neurogenesis | |
signal transduction |
Microarray ID | 1369252_a_at |
---|---|
M15682_at | |
rc_AI145571_at | |
A_43_P12419 | |
NM_024354 | |
106106_at | |
1421202_at | |
1421203_at | |
110658_at | |
A_51_P104487 | |
NM_015730 | |
L35901 | |
216900_s_at | |
216886_at | |
34447_at | |
85309_at | |
85311_at | |
206735_at | |
206736_x_at | |
U62433_at | |
A_23_P210395 | |
I_966162 |
MGI ID | 87888 |
---|
GO Molecular Function | extracellular ligand-gated ion channel activity |
---|---|
ion channel activity | |
neurotransmitter receptor activity | |
GABA-A receptor activity | |
nicotinic acetylcholine-activated cation-selective channel activity | |
receptor activity | |
acetylcholine receptor activity |
GO ID | GO:0005230 |
---|---|
GO:0005216 | |
GO:0030594 | |
GO:0006810 | |
GO:0006811 | |
GO:0007268 | |
GO:0016020 | |
GO:0005892 | |
GO:0016021 | |
GO:0004890 | |
GO:0004889 | |
GO:0004872 | |
GO:0007271 | |
GO:0007600 | |
GO:0007610 | |
GO:0005624 | |
GO:0015464 | |
GO:0007399 | |
GO:0007165 |
Swiss-Prot Accession | P43681 |
---|
OMIM ID | OMIM:118504 |
---|---|
OMIM:600513 | |
OMIM:188890 |
Alias | Chrna4 |
---|---|
NARAC | |
cholinergic receptor, nicotinic, alpha polypeptide 4 | |
Neuronal nicotinic acetylcholine receptor alpha 4 subunit | |
EBN1 | |
Acra4 | |
ENFL1 | |
Acra-4 | |
alpha4 nAChR | |
a4 nicotinic receptor | |
acetylcholine receptor alpha 4 neural | |
ACETYLCHOLINE RECEPTOR, NEURONAL NICOTINIC, ALPHA-4 SUBUNIT | |
acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit | |
alpha-4 AChR | |
NACRA4 | |
neuronal nicotinic acetylcholine receptor alpha-4 subunit | |
cholinergic receptor, nicotinic, alpha polypeptide 4 precursor | |
BFNC | |
cholinergic receptor, nicotinic, alpha polypeptide IV | |
EBN I | |
ENFL I | |
Neuronal acetylcholine receptor protein, alpha-4 chain precursor | |
neuronal nicotinic cholinergic receptor alpha 4 subunit precursor |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 25590 |
---|---|
11438 | |
1137 |
Source | ResNet |
---|
RGD ID | 2346 |
---|
Pathway | path |
---|---|
path1 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.9697 |
---|---|
Mm.252369 | |
Hs.10734 | |
Mm.40959 |
Group | New Group |
---|