Protein : CHRNA4

Connectivity 8
Notes The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors respond by undergoing an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The protein encoded by this gene is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene appear to account for a small proportion of the cases of nocturnal frontal lobe epilepsy.
Hugo ID 1958
Name CHRNA4
Description cholinergic receptor, nicotinic, alpha polypeptide 4
URN urn:agi-llid:1137

GO Cellular Component integral to membrane
membrane
nicotinic acetylcholine-gated receptor-channel complex
membrane fraction
postsynaptic membrane

Cell Localization Plasma membrane
Cytoplasm

GO Biological Process ion transport
synaptic transmission
transport
behavior
sensory perception
synaptic transmission, cholinergic
neurogenesis
signal transduction

Microarray ID 1369252_a_at
M15682_at
rc_AI145571_at
A_43_P12419
NM_024354
106106_at
1421202_at
1421203_at
110658_at
A_51_P104487
NM_015730
L35901
216900_s_at
216886_at
34447_at
85309_at
85311_at
206735_at
206736_x_at
U62433_at
A_23_P210395
I_966162

GenBank ID AF007212
NW_047667
NM_024354
NP_077330
AAB64439
L31620
AAC97071
M15682
AAA41676
BC053013
NT_080080
NM_015730
NP_056545
AB010002
BAA25752
AF225912
AAF34716
AF325347
AAL37363
AK034228
BAC28638
AK083157
BAC38788
AAH53013
O70174
BM710937
U62433
NT_011333
NM_000744
NP_000735
L35901
AAA64743
AAB40111
X87629
CAA60959
X89741
CAA61893
X89742
X89743
X89744
X89745
X89746
Y08421
CAA69698
P43681

MGI ID 87888

GO Molecular Function extracellular ligand-gated ion channel activity
ion channel activity
neurotransmitter receptor activity
GABA-A receptor activity
nicotinic acetylcholine-activated cation-selective channel activity
receptor activity
acetylcholine receptor activity

GO ID GO:0005230
GO:0005216
GO:0030594
GO:0006810
GO:0006811
GO:0007268
GO:0016020
GO:0005892
GO:0016021
GO:0004890
GO:0004889
GO:0004872
GO:0007271
GO:0007600
GO:0007610
GO:0005624
GO:0015464
GO:0007399
GO:0007165

Swiss-Prot Accession P43681

OMIM ID OMIM:118504
OMIM:600513
OMIM:188890

Alias Chrna4
NARAC
cholinergic receptor, nicotinic, alpha polypeptide 4
Neuronal nicotinic acetylcholine receptor alpha 4 subunit
EBN1
Acra4
ENFL1
Acra-4
alpha4 nAChR
a4 nicotinic receptor
acetylcholine receptor alpha 4 neural
ACETYLCHOLINE RECEPTOR, NEURONAL NICOTINIC, ALPHA-4 SUBUNIT
acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit
alpha-4 AChR
NACRA4
neuronal nicotinic acetylcholine receptor alpha-4 subunit
cholinergic receptor, nicotinic, alpha polypeptide 4 precursor
BFNC
cholinergic receptor, nicotinic, alpha polypeptide IV
EBN I
ENFL I
Neuronal acetylcholine receptor protein, alpha-4 chain precursor
neuronal nicotinic cholinergic receptor alpha 4 subunit precursor

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 25590
11438
1137

Source ResNet

RGD ID 2346

Pathway path
path1
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.9697
Mm.252369
Hs.10734
Mm.40959

Group New Group