Protein : PRKCZ

Connectivity 230
Notes Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a constitutive kinase activity which is independent of calcium, and PKC activators, phosphatidylserine and diacylglycerol. Furthermore, it is insensitive to PKC inhibitors and cannot be activated by phorbol ester. The structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC.
Hugo ID 9412
Name PRKCZ
Description protein kinase C, zeta
URN urn:agi-llid:5590

GO Cellular Component cytoplasm
membrane fraction
plasma membrane

Cell Localization Cytoplasm

GO Biological Process intracellular signaling cascade
protein amino acid phosphorylation
signal transduction
anti-apoptosis

EC Number 2.7.1.37

MGI ID 97602

Swiss-Prot Accession Q05513

OMIM ID OMIM:176982

Alias Prkcz
Pkcz
r14-3-3
protein kinase C, zeta
PKC-zeta
zetaPKC
PKC2
NPKC-zeta

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 25522
64299
18762
97163
97193
100028
5590

RGD ID 3399

Pathway Insulin Receptor Signaling
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.1109
Mm.28561
Hs.407181

Group Kinases
nucleotide binding
lipid binding
New Group