Connectivity | 17 |
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Notes | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene. |
Hugo ID | 9059 |
Name | PLCB4 |
Description | phospholipase C, beta 4 |
URN | urn:agi-llid:5332 |
Cell Localization | Cytoplasm |
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GO Biological Process | intracellular signaling cascade |
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lipid metabolism | |
phototransduction | |
signal transduction | |
lipid catabolism |
EC Number | 3.1.4.11 |
---|
Microarray ID | 1370489_a_at |
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1386962_at | |
L15556_at | |
AF027571_s_at | |
116455_at | |
1435771_at | |
1425338_at | |
1425339_at | |
A_51_P211659 | |
AF022804 | |
L41349 | |
51335_at | |
35654_at | |
900_at | |
901_g_at | |
203895_at | |
203896_s_at | |
240728_at | |
80794_at | |
L41349_at | |
rc_n35406_s_at | |
39213_AT | |
A_23_P28898 | |
I_961574 |
State | phospholipase C beta 4 isoform a |
---|---|
phospholipase C beta 4 isoform b |
State Description | Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). |
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Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. |
MGI ID | 107464 |
---|
GO Molecular Function | phospholipase C activity |
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ATP binding | |
phosphoinositide phospholipase C activity | |
signal transducer activity | |
hydrolase activity |
GO ID | GO:0004629 |
---|---|
GO:0005524 | |
GO:0004435 | |
GO:0006629 | |
GO:0007242 | |
GO:0007165 | |
GO:0016042 | |
GO:0004871 | |
GO:0016787 |
Swiss-Prot Accession | Q15147 |
---|
OMIM ID | OMIM:600810 |
---|
Alias | Plcb4 |
---|---|
Beta4aa | |
phospholipase C, beta 4 | |
RATBETA4AA | |
Phospholipase C beta4 | |
Phospholipase C (BETA4) | |
Phospholipase C , beta4 | |
phospholipase C beta 4 | |
PLC-beta-4 | |
phosphoinositidase C | |
inositoltrisphosphohydrolase | |
phosphoinositide phospholipase C | |
triphosphoinositide phosphodiesterase | |
monophosphatidylinositol phosphodiesterase | |
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate | |
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 | |
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate phosphodiesterase | |
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta IV | |
phospholipase C, beta IV | |
PLC-beta IV |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 25031 |
---|---|
18798 | |
5332 |
Source | ResNet |
---|
RGD ID | 3345 |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.6155 |
---|---|
Mm.38009 | |
Hs.151408 |
Group | metal ion binding |
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