Protein : PLCB4

Connectivity 17
Notes The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.
Hugo ID 9059
Name PLCB4
Description phospholipase C, beta 4
URN urn:agi-llid:5332

Cell Localization Cytoplasm

GO Biological Process intracellular signaling cascade
lipid metabolism
phototransduction
signal transduction
lipid catabolism

EC Number 3.1.4.11

Microarray ID 1370489_a_at
1386962_at
L15556_at
AF027571_s_at
116455_at
1435771_at
1425338_at
1425339_at
A_51_P211659
AF022804
L41349
51335_at
35654_at
900_at
901_g_at
203895_at
203896_s_at
240728_at
80794_at
L41349_at
rc_n35406_s_at
39213_AT
A_23_P28898
I_961574

GenBank ID L15556
AF027571
AAC24984
AF031370
AAC98145
AAK13557
L18962
U57836
AAD10403
NP_077329
AF332071
NT_078378
NM_013829
NP_038857
AF022804
AAD01752
AAK56099
AF332072
AAK56100
AK047161
BAC32975
BC061201
AAH61201
AK025027
AL117633
AL844332
BG220268
BI439140
L41349
NT_011387
NM_000933
NP_000924
AK054754
AK057634
BX648680
AAB02027
Q15147
NP_877949

State phospholipase C beta 4 isoform a
phospholipase C beta 4 isoform b

State Description Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.

MGI ID 107464

GO Molecular Function phospholipase C activity
ATP binding
phosphoinositide phospholipase C activity
signal transducer activity
hydrolase activity

GO ID GO:0004629
GO:0005524
GO:0004435
GO:0006629
GO:0007242
GO:0007165
GO:0016042
GO:0004871
GO:0016787

Swiss-Prot Accession Q15147

OMIM ID OMIM:600810

Alias Plcb4
Beta4aa
phospholipase C, beta 4
RATBETA4AA
Phospholipase C beta4
Phospholipase C (BETA4)
Phospholipase C , beta4
phospholipase C beta 4
PLC-beta-4
phosphoinositidase C
inositoltrisphosphohydrolase
phosphoinositide phospholipase C
triphosphoinositide phosphodiesterase
monophosphatidylinositol phosphodiesterase
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate phosphodiesterase
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta IV
phospholipase C, beta IV
PLC-beta IV

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 25031
18798
5332

Source ResNet

RGD ID 3345

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.6155
Mm.38009
Hs.151408

Group metal ion binding