| Connectivity | 17 |
|---|---|
| Notes | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene. |
| Hugo ID | 9059 |
| Name | PLCB4 |
| Description | phospholipase C, beta 4 |
| URN | urn:agi-llid:5332 |
| Cell Localization | Cytoplasm |
|---|
| GO Biological Process | intracellular signaling cascade |
|---|---|
| lipid metabolism | |
| phototransduction | |
| signal transduction | |
| lipid catabolism |
| EC Number | 3.1.4.11 |
|---|
| Microarray ID | 1370489_a_at |
|---|---|
| 1386962_at | |
| L15556_at | |
| AF027571_s_at | |
| 116455_at | |
| 1435771_at | |
| 1425338_at | |
| 1425339_at | |
| A_51_P211659 | |
| AF022804 | |
| L41349 | |
| 51335_at | |
| 35654_at | |
| 900_at | |
| 901_g_at | |
| 203895_at | |
| 203896_s_at | |
| 240728_at | |
| 80794_at | |
| L41349_at | |
| rc_n35406_s_at | |
| 39213_AT | |
| A_23_P28898 | |
| I_961574 |
| State | phospholipase C beta 4 isoform a |
|---|---|
| phospholipase C beta 4 isoform b |
| State Description | Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). |
|---|---|
| Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. |
| MGI ID | 107464 |
|---|
| GO Molecular Function | phospholipase C activity |
|---|---|
| ATP binding | |
| phosphoinositide phospholipase C activity | |
| signal transducer activity | |
| hydrolase activity |
| GO ID | GO:0004629 |
|---|---|
| GO:0005524 | |
| GO:0004435 | |
| GO:0006629 | |
| GO:0007242 | |
| GO:0007165 | |
| GO:0016042 | |
| GO:0004871 | |
| GO:0016787 |
| Swiss-Prot Accession | Q15147 |
|---|
| OMIM ID | OMIM:600810 |
|---|
| Alias | Plcb4 |
|---|---|
| Beta4aa | |
| phospholipase C, beta 4 | |
| RATBETA4AA | |
| Phospholipase C beta4 | |
| Phospholipase C (BETA4) | |
| Phospholipase C , beta4 | |
| phospholipase C beta 4 | |
| PLC-beta-4 | |
| phosphoinositidase C | |
| inositoltrisphosphohydrolase | |
| phosphoinositide phospholipase C | |
| triphosphoinositide phosphodiesterase | |
| monophosphatidylinositol phosphodiesterase | |
| 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate | |
| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 | |
| 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate phosphodiesterase | |
| 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta IV | |
| phospholipase C, beta IV | |
| PLC-beta IV |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 25031 |
|---|---|
| 18798 | |
| 5332 |
| Source | ResNet |
|---|
| RGD ID | 3345 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.6155 |
|---|---|
| Mm.38009 | |
| Hs.151408 |
| Group | metal ion binding |
|---|