Connectivity | 18 |
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Notes | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. |
Hugo ID | 6866 |
Name | MAP4K4 |
Description | mitogen-activated protein kinase kinase kinase kinase 4 |
URN | urn:agi-llid:9448 |
GO Cellular Component | cellular_component unknown |
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Cell Localization | Cytoplasm |
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GO Biological Process | protein amino acid phosphorylation |
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protein kinase cascade | |
response to stress |
Microarray ID | 102195_at |
---|---|
1422615_at | |
102601_f_at | |
161295_r_at | |
U88984_s_at | |
1448050_s_at | |
A_51_P268053 | |
NM_008696 | |
A_65_P06571 | |
H3105G04-3 | |
35694_at | |
91812_at | |
206571_s_at | |
222547_at | |
222548_s_at | |
86235_at | |
RC_N54067_at | |
A_32_P440373 | |
I_3285480 | |
A_23_P108604 | |
I_939089 |
State | isoform 1 |
---|---|
isoform 2 | |
isoform 3 |
State Description | Transcript Variant: This variant (1) lacks two in-frame coding segments, and contains an extra in-frame coding segment, compared to variant 2. The resulting isoform (1) thus lacks two regions, and contains an additional region, as compared to isoform 2. |
---|---|
Transcript Variant: This variant (2) encodes the longest isoform (2). | |
Transcript Variant: This variant (3) lacks two in-frame coding segments compared to variant 2. The resulting isoform (3) thus lacks two regions, as compared to isoform 2. |
MGI ID | 1349394 |
---|
GO Molecular Function | small GTPase regulatory/interacting protein activity |
---|---|
protein-tyrosine kinase activity | |
ATP binding | |
protein serine/threonine kinase activity | |
protein kinase activity | |
transferase activity |
GO ID | GO:0005083 |
---|---|
GO:0004713 | |
GO:0005524 | |
GO:0004674 | |
GO:0004672 | |
GO:0016740 | |
GO:0006468 | |
GO:0007243 | |
GO:0006950 | |
GO:0008372 |
Swiss-Prot Accession | O95819 |
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OMIM ID | OMIM:604666 |
---|
Alias | Map4k4 |
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HGK | |
Nik | |
mitogen-activated protein kinase kinase kinase kinase 4 | |
HPK/GCK-like kinase | |
NCK interacting kinase | |
AU045934 | |
expressed sequence AU045934 | |
hepatocyte progenitor kinase-like/germinal center kinase-like kinase | |
FLH21957 | |
FLJ20373 | |
KIAA0687 | |
MAPKKKK4 | |
mitogen-activated protein kinase kinase kinase kinase IV | |
Nesk | |
Nik related kinase | |
hypothetical protein FLJ20373 |
Organism | Mus musculus |
---|---|
Human |
LocusLink ID | 18078 |
---|---|
26921 | |
98612 | |
9448 | |
54912 |
Source | ResNet |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Mm.19073 |
---|---|
Hs.531607 | |
Mm.987 | |
Hs.3628 |
Group | Kinases |
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nucleotide binding |