Protein : MAP4K4

Connectivity 18
Notes The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway.
Hugo ID 6866
Name MAP4K4
Description mitogen-activated protein kinase kinase kinase kinase 4
URN urn:agi-llid:9448

GO Cellular Component cellular_component unknown

Cell Localization Cytoplasm

GO Biological Process protein amino acid phosphorylation
protein kinase cascade
response to stress

Microarray ID 102195_at
1422615_at
102601_f_at
161295_r_at
U88984_s_at
1448050_s_at
A_51_P268053
NM_008696
A_65_P06571
H3105G04-3
35694_at
91812_at
206571_s_at
222547_at
222548_s_at
86235_at
RC_N54067_at
A_32_P440373
I_3285480
A_23_P108604
I_939089

GenBank ID U88984
NT_080070
NM_008696
NP_032722
AAC53165
P97820
AF096300
AL137755
AB014587
NT_022171
NM_004834
NP_004825
NM_145686
NP_663719
NM_145687
NP_663720
AB013385
BAA33714
BAA31662
AAD16137
AK025610
CAB70907
AY212247
AAO32626
O95819

State isoform 1
isoform 2
isoform 3

State Description Transcript Variant: This variant (1) lacks two in-frame coding segments, and contains an extra in-frame coding segment, compared to variant 2. The resulting isoform (1) thus lacks two regions, and contains an additional region, as compared to isoform 2.
Transcript Variant: This variant (2) encodes the longest isoform (2).
Transcript Variant: This variant (3) lacks two in-frame coding segments compared to variant 2. The resulting isoform (3) thus lacks two regions, as compared to isoform 2.

MGI ID 1349394

GO Molecular Function small GTPase regulatory/interacting protein activity
protein-tyrosine kinase activity
ATP binding
protein serine/threonine kinase activity
protein kinase activity
transferase activity

GO ID GO:0005083
GO:0004713
GO:0005524
GO:0004674
GO:0004672
GO:0016740
GO:0006468
GO:0007243
GO:0006950
GO:0008372

Swiss-Prot Accession O95819

OMIM ID OMIM:604666

Alias Map4k4
HGK
Nik
mitogen-activated protein kinase kinase kinase kinase 4
HPK/GCK-like kinase
NCK interacting kinase
AU045934
expressed sequence AU045934
hepatocyte progenitor kinase-like/germinal center kinase-like kinase
FLH21957
FLJ20373
KIAA0687
MAPKKKK4
mitogen-activated protein kinase kinase kinase kinase IV
Nesk
Nik related kinase
hypothetical protein FLJ20373

Organism Mus musculus
Human

LocusLink ID 18078
26921
98612
9448
54912

Source ResNet

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Mm.19073
Hs.531607
Mm.987
Hs.3628

Group Kinases
nucleotide binding