| Connectivity | 95 |
|---|---|
| Notes | RAP1A belongs to a family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. According to one study it can suppress the transformed phenotype of a Kirsten transformed cell line and thus may be involved in the negative growth regulation of certain cell types. |
| Hugo ID | 9855 |
| Name | RAP1A |
| Description | RAP1A, member of RAS oncogene family |
| URN | urn:agi-llid:5906 |
| GO Cellular Component | membrane |
|---|
| Cell Localization | Plasma membrane |
|---|
| GO Biological Process | negative regulation of cell cycle |
|---|---|
| small GTPase mediated signal transduction | |
| regulation of cell cycle | |
| signal transduction |
| Microarray ID | 1388615_at |
|---|---|
| rc_aa925664_at | |
| 93962_at | |
| 1448020_at | |
| aa210264_s_at | |
| 1424139_at | |
| 100048_at | |
| msa.10101.0_f_at | |
| A_51_P228632 | |
| BC011105 | |
| A_65_P06206 | |
| H3065D10-3 | |
| 38756_at | |
| 1848_at | |
| 202362_at | |
| 228548_at | |
| 45178_at | |
| 70281_at | |
| RC_AA021557_at | |
| RC_AA437308_s_at | |
| M22995_at | |
| 229016_s_at | |
| A_23_P51746 | |
| I_930705 |
| GenBank ID | NW_047627 |
|---|---|
| XM_215669 | |
| XP_215669 | |
| BC011105 | |
| NT_039239 | |
| NM_145541 | |
| NP_663516 | |
| BC051419 | |
| M22995 | |
| NT_019273 | |
| NM_002884 | |
| NP_002875 | |
| BC014086 | |
| AAH14086 | |
| AAA36150 | |
| X12533 | |
| CAA31051 | |
| P10113 |
| State | GDP-bound |
|---|---|
| GTP-bound | |
| Rap1-GDP |
| MGI ID | 97852 |
|---|
| GO Molecular Function | small monomeric GTPase activity |
|---|---|
| RAS small monomeric GTPase activity | |
| GTP binding |
| GO ID | GO:0003925 |
|---|---|
| GO:0007264 | |
| GO:0003930 | |
| GO:0005525 | |
| GO:0007165 | |
| GO:0045786 |
| Swiss-Prot Accession | P10113 |
|---|
| OMIM ID | OMIM:179520 |
|---|
| Alias | RAP-1A |
|---|---|
| Ras-related protein RAP-1A | |
| AI848598 | |
| expressed sequence AI848598 | |
| Rap1a | |
| G-22K | |
| Krev-1 | |
| RAS-related protein-1a | |
| GTP-binding protein SMG-P21A | |
| KREV1 | |
| SMGP21 | |
| RAP1A, member of RAS oncogene family | |
| RAS-related protein RAP1A | |
| RAPA_HUMAN | |
| transforming protein rap1a | |
| GTP-binding protein SMG-P21A | |
| KREV-1 protein | |
| Rap1a GTPase | |
| similar to rap1A protein - turkey | |
| RAPA |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 295347 |
|---|---|
| 19388 | |
| 99734 | |
| 109905 | |
| 229684 | |
| 5906 | |
| 228515 |
| Source | ResNet |
|---|
| Pathway | Integrin Signaling |
|---|---|
| G-protein Coupled Receptor signaling | |
| MAPK-ERK in Growth and Differentiation | |
| path | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.106321 |
|---|---|
| Mm.333868 | |
| Hs.865 | |
| Mm.967 | |
| Mm.227048 |
| Group | nucleotide binding |
|---|