Protein : CACNA1B

Connectivity 85
Notes Voltage-dependent Ca(2+) channels are multisubunit complexes found in the membrane of many excitable cells that regulate calcium entry (see MIM 601011). N-type calcium channels, which control neurotransmitter release from neurons, are dihydropyridine-insensitive and omega-conotoxin-sensitive. The alpha-1 subunit forms the pore through which calcium enters the cell, and is encoded by a family of at least 5 genes.[supplied by OMIM]
Hugo ID 1389
Name CACNA1B
Description calcium channel, voltage-dependent, L type, alpha 1B subunit
URN urn:agi-llid:774

GO Cellular Component integral to membrane
membrane
voltage-gated calcium channel complex

Cell Localization Plasma membrane

GO Biological Process calcium ion transport
cation transport
ion transport
locomotory behavior
neurotransmitter secretion
regulation of blood pressure
regulation of heart rate
synaptic transmission

Microarray ID 1370444_at
1371175_a_at
AF055477_at
m92905_s_at
98360_at
1425812_a_at
U04999_s_at
Msa.202.0_at
A_51_P206573
NM_007579
M94172
33960_s_at
207162_s_at
M94172_s_at
A_32_P153773
I_2031539
A_23_P159622
I_964947
A_23_P84849
I_965232

GenBank ID AF055477
NW_047651
XM_346648
XP_346649
AF146632
AAD31922
AF146633
AAD31923
AF222338
AAF70137
AAC29043
AF222337
AAF70136
AF389419
AAK71643
NP_671482
U04999
NT_039206
NM_007579
NP_031605
AF042317
AAB97840
AK081230
AAB60437
O55017
M94172
NT_023929
NM_000718
NP_000709
AAA51897
M94173
AAA51898
Q00975

MGI ID 88296

GO Molecular Function voltage-gated ion channel activity
ion channel activity
cation channel activity
calcium channel activity
ATP binding
voltage-gated calcium channel activity
calcium ion binding

GO ID GO:0005244
GO:0005216
GO:0005261
GO:0005262
GO:0005524
GO:0005245
GO:0005509
GO:0007626
GO:0006812
GO:0008016
GO:0006811
GO:0008217
GO:0006816
GO:0016020
GO:0005891
GO:0016021
GO:0007268

Swiss-Prot Accession Q00975

Keyword adrenoceptor

OMIM ID OMIM:601012

Alias Cacna1b
calcium channel, voltage-dependent, N type, alpha 1B subunit
Cav2.2
Cchn1a
calcium channel, voltage-dependent, L type, alpha 1B subunit
alpha(1B)
AW060892
CACNN
calcium channel, N type
calcium channel, voltage-dependent, alpha 1B subunit, N type
Ca-alpha-1B
CACNL1A5
4921522D01Rik
BIII
Brain calcium channel III
CACH5
RIKEN cDNA 4921522D01 gene
Voltage-dependent N-type calcium channel alpha-1B subunit
Calcium channel, L type, alpha-1 polypeptide isoform 5

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 257648
12287
99299
99310
99436
774

Source ResNet

RGD ID 628852

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.85880
Mm.4424
Hs.69949

Group nucleotide binding
metal ion binding