Protein : CAMK2G

Connectivity 93
Notes The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined.
Hugo ID 1463
Name CAMK2G
Description calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
URN urn:agi-llid:818

Cell Localization Cytoplasm

GO Biological Process protein amino acid phosphorylation
regulation of long-term neuronal synaptic plasticity
response to hypoxia
response to oxidative stress
G1/S transition of mitotic cell cycle
autophosphorylation
calcium ion transport
insulin secretion
signal transduction

EC Number 2.7.1.123

Microarray ID 1369993_at
J04063_at
U73503_at
s71570_s_at
A_43_P13229
NM_133605
1423941_at
A_51_P132849
AK031213
A_65_P18123
C0912G07-3
U66063 >a
U66063 >b
212757_s_at
212669_at
214322_at
32104_i_at
32105_f_at
39388_at
83402_at
650_s_at
L07044_at
U81554_at
U50360_s_at
208095_s_at
rc_aa151393_at
rc_n39414_s_at
31670_S_AT
A_32_P931898
I_3253871

GenBank ID J04063
NW_047445
NM_133605
NP_598289
AAA41857
S71571
AAB30671
U73503
AAC53138
AK078311
NT_039596
NM_178597
NP_848712
AF395884
AAK84142
AK031213
BAC27303
AK054406
BAC35766
BAC37215
AK081969
BC019162
AAH19162
BC025597
AAH25597
BC034044
L07043
BC021269
U66063
U50359
U50360
NT_008583
NM_001222
NP_001213
NM_172169
NP_751909
NM_172170
NP_751910
NM_172171
NP_751911
NM_172172
NP_751912
NM_172173
NP_751913
AF415177
AAM33514
AK026309
AK094774
AK095576
BC012795
AAH21269
AAH34044
BC037928
AAB61379
L07044
U32472
AAA75201
U32473
AAA75202
U32509
AAA75203
AAB16864
AAB16865
AAB80847
U66064
AAB80848
Q13555

State calcium/calmodulin-dependent protein kinase II gamma isoform 4
calcium/calmodulin-dependent protein kinase II gamma isoform 2
calcium/calmodulin-dependent protein kinase II gamma isoform 3
calcium/calmodulin-dependent protein kinase II gamma isoform 1
calcium/calmodulin-dependent protein kinase II gamma isoform 5
calcium/calmodulin-dependent protein kinase II gamma isoform 6

State Description Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1.
Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1.
Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform 1.
Transcript Variant: This variant (5) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (5) contains a shorter and distinct C-terminus compared to isoform 1.
Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1.

MGI ID 88259

GO Molecular Function calmodulin-dependent protein kinase I activity
calcium/calmodulin-dependent protein kinase activity
ATP binding
protein serine/threonine kinase activity
calmodulin binding
protein kinase activity
transferase activity
protein-tyrosine kinase activity
kinase activity
signal transducer activity

GO ID GO:0004684
GO:0004685
GO:0005524
GO:0004674
GO:0005516
GO:0004672
GO:0016740
GO:0006468
GO:0048169
GO:0004713
GO:0016301
GO:0004871
GO:0007165

Swiss-Prot Accession Q13555

OMIM ID OMIM:602123

Alias Camk2g
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Camkg
calcium/calmodulin -dependent protein kinase II gamma
CaMK II
Ca2+/calmodulin-dependent protein kinase II
5930429P18Rik
CAMK
CAMK-II
CaM kinase II
MGC26678
calcium/calmodulin-dependent protein kinase (CaM kinase) gamma
calcium/calmodulin-dependent protein kinase II gamma isoform 1
calcium/calmodulin-dependent protein kinase II gamma isoform 2
calcium/calmodulin-dependent protein kinase II gamma isoform 3
calcium/calmodulin-dependent protein kinase II gamma isoform 4
calcium/calmodulin-dependent protein kinase II gamma isoform 5
calcium/calmodulin-dependent protein kinase II gamma isoform 6
calcium/calmodulin-dependent protein kinase II gamma isoform I
calcium/calmodulin-dependent protein kinase II gamma isoform II
calcium/calmodulin-dependent protein kinase II gamma isoform III
calcium/calmodulin-dependent protein kinase II gamma isoform IV
calcium/calmodulin-dependent protein kinase II gamma isoform V
calcium/calmodulin-dependent protein kinase II gamma isoform VI
CaM kinase II gamma isoform

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 171140
12325
218813
818

Source ResNet

RGD ID 621802

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.10961
Mm.235182
Hs.12436

Group Kinases
nucleotide binding
protein binding