Connectivity | 93 |
---|---|
Notes | The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined. |
Hugo ID | 1463 |
Name | CAMK2G |
Description | calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma |
URN | urn:agi-llid:818 |
Cell Localization | Cytoplasm |
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GO Biological Process | protein amino acid phosphorylation |
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regulation of long-term neuronal synaptic plasticity | |
response to hypoxia | |
response to oxidative stress | |
G1/S transition of mitotic cell cycle | |
autophosphorylation | |
calcium ion transport | |
insulin secretion | |
signal transduction |
EC Number | 2.7.1.123 |
---|
Microarray ID | 1369993_at |
---|---|
J04063_at | |
U73503_at | |
s71570_s_at | |
A_43_P13229 | |
NM_133605 | |
1423941_at | |
A_51_P132849 | |
AK031213 | |
A_65_P18123 | |
C0912G07-3 | |
U66063 >a | |
U66063 >b | |
212757_s_at | |
212669_at | |
214322_at | |
32104_i_at | |
32105_f_at | |
39388_at | |
83402_at | |
650_s_at | |
L07044_at | |
U81554_at | |
U50360_s_at | |
208095_s_at | |
rc_aa151393_at | |
rc_n39414_s_at | |
31670_S_AT | |
A_32_P931898 | |
I_3253871 |
State | calcium/calmodulin-dependent protein kinase II gamma isoform 4 |
---|---|
calcium/calmodulin-dependent protein kinase II gamma isoform 2 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 3 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 1 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 5 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 6 |
State Description | Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1. |
---|---|
Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1. | |
Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1. | |
Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform 1. | |
Transcript Variant: This variant (5) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (5) contains a shorter and distinct C-terminus compared to isoform 1. | |
Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1. |
MGI ID | 88259 |
---|
GO Molecular Function | calmodulin-dependent protein kinase I activity |
---|---|
calcium/calmodulin-dependent protein kinase activity | |
ATP binding | |
protein serine/threonine kinase activity | |
calmodulin binding | |
protein kinase activity | |
transferase activity | |
protein-tyrosine kinase activity | |
kinase activity | |
signal transducer activity |
GO ID | GO:0004684 |
---|---|
GO:0004685 | |
GO:0005524 | |
GO:0004674 | |
GO:0005516 | |
GO:0004672 | |
GO:0016740 | |
GO:0006468 | |
GO:0048169 | |
GO:0004713 | |
GO:0016301 | |
GO:0004871 | |
GO:0007165 |
Swiss-Prot Accession | Q13555 |
---|
OMIM ID | OMIM:602123 |
---|
Alias | Camk2g |
---|---|
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | |
Camkg | |
calcium/calmodulin -dependent protein kinase II gamma | |
CaMK II | |
Ca2+/calmodulin-dependent protein kinase II | |
5930429P18Rik | |
CAMK | |
CAMK-II | |
CaM kinase II | |
MGC26678 | |
calcium/calmodulin-dependent protein kinase (CaM kinase) gamma | |
calcium/calmodulin-dependent protein kinase II gamma isoform 1 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 2 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 3 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 4 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 5 | |
calcium/calmodulin-dependent protein kinase II gamma isoform 6 | |
calcium/calmodulin-dependent protein kinase II gamma isoform I | |
calcium/calmodulin-dependent protein kinase II gamma isoform II | |
calcium/calmodulin-dependent protein kinase II gamma isoform III | |
calcium/calmodulin-dependent protein kinase II gamma isoform IV | |
calcium/calmodulin-dependent protein kinase II gamma isoform V | |
calcium/calmodulin-dependent protein kinase II gamma isoform VI | |
CaM kinase II gamma isoform |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 171140 |
---|---|
12325 | |
218813 | |
818 |
Source | ResNet |
---|
RGD ID | 621802 |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.10961 |
---|---|
Mm.235182 | |
Hs.12436 |
Group | Kinases |
---|---|
nucleotide binding | |
protein binding |