| Connectivity | 93 |
|---|---|
| Notes | The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Six alternatively spliced variants that encode six different isoforms have been characterized to date. Additional alternative splice variants that encode different isoforms have been described, but their full-length nature has not been determined. |
| Hugo ID | 1463 |
| Name | CAMK2G |
| Description | calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma |
| URN | urn:agi-llid:818 |
| Cell Localization | Cytoplasm |
|---|
| GO Biological Process | protein amino acid phosphorylation |
|---|---|
| regulation of long-term neuronal synaptic plasticity | |
| response to hypoxia | |
| response to oxidative stress | |
| G1/S transition of mitotic cell cycle | |
| autophosphorylation | |
| calcium ion transport | |
| insulin secretion | |
| signal transduction |
| EC Number | 2.7.1.123 |
|---|
| Microarray ID | 1369993_at |
|---|---|
| J04063_at | |
| U73503_at | |
| s71570_s_at | |
| A_43_P13229 | |
| NM_133605 | |
| 1423941_at | |
| A_51_P132849 | |
| AK031213 | |
| A_65_P18123 | |
| C0912G07-3 | |
| U66063 >a | |
| U66063 >b | |
| 212757_s_at | |
| 212669_at | |
| 214322_at | |
| 32104_i_at | |
| 32105_f_at | |
| 39388_at | |
| 83402_at | |
| 650_s_at | |
| L07044_at | |
| U81554_at | |
| U50360_s_at | |
| 208095_s_at | |
| rc_aa151393_at | |
| rc_n39414_s_at | |
| 31670_S_AT | |
| A_32_P931898 | |
| I_3253871 |
| State | calcium/calmodulin-dependent protein kinase II gamma isoform 4 |
|---|---|
| calcium/calmodulin-dependent protein kinase II gamma isoform 2 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 3 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 1 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 5 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 6 |
| State Description | Transcript Variant: This variant (4) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (4), that is missing internal segments compared to isoform 1. |
|---|---|
| Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1. | |
| Transcript Variant: This variant (3) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (3), that is missing an internal segment compared to isoform 1. | |
| Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform 1. | |
| Transcript Variant: This variant (5) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (5) contains a shorter and distinct C-terminus compared to isoform 1. | |
| Transcript Variant: This variant (6) lacks in-frame segments of the coding region, compared to variant 1. It encodes a shorter isoform (6), that is missing internal segments compared to isoform 1. |
| MGI ID | 88259 |
|---|
| GO Molecular Function | calmodulin-dependent protein kinase I activity |
|---|---|
| calcium/calmodulin-dependent protein kinase activity | |
| ATP binding | |
| protein serine/threonine kinase activity | |
| calmodulin binding | |
| protein kinase activity | |
| transferase activity | |
| protein-tyrosine kinase activity | |
| kinase activity | |
| signal transducer activity |
| GO ID | GO:0004684 |
|---|---|
| GO:0004685 | |
| GO:0005524 | |
| GO:0004674 | |
| GO:0005516 | |
| GO:0004672 | |
| GO:0016740 | |
| GO:0006468 | |
| GO:0048169 | |
| GO:0004713 | |
| GO:0016301 | |
| GO:0004871 | |
| GO:0007165 |
| Swiss-Prot Accession | Q13555 |
|---|
| OMIM ID | OMIM:602123 |
|---|
| Alias | Camk2g |
|---|---|
| calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | |
| Camkg | |
| calcium/calmodulin -dependent protein kinase II gamma | |
| CaMK II | |
| Ca2+/calmodulin-dependent protein kinase II | |
| 5930429P18Rik | |
| CAMK | |
| CAMK-II | |
| CaM kinase II | |
| MGC26678 | |
| calcium/calmodulin-dependent protein kinase (CaM kinase) gamma | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 1 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 2 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 3 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 4 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 5 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform 6 | |
| calcium/calmodulin-dependent protein kinase II gamma isoform I | |
| calcium/calmodulin-dependent protein kinase II gamma isoform II | |
| calcium/calmodulin-dependent protein kinase II gamma isoform III | |
| calcium/calmodulin-dependent protein kinase II gamma isoform IV | |
| calcium/calmodulin-dependent protein kinase II gamma isoform V | |
| calcium/calmodulin-dependent protein kinase II gamma isoform VI | |
| CaM kinase II gamma isoform |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 171140 |
|---|---|
| 12325 | |
| 218813 | |
| 818 |
| Source | ResNet |
|---|
| RGD ID | 621802 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.10961 |
|---|---|
| Mm.235182 | |
| Hs.12436 |
| Group | Kinases |
|---|---|
| nucleotide binding | |
| protein binding |