| Connectivity | 135 |
|---|---|
| Notes | Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM] |
| Hugo ID | 11433 |
| Name | STX1A |
| Description | syntaxin 1A (brain) |
| URN | urn:agi-llid:6804 |
| GO Cellular Component | integral to membrane |
|---|---|
| kinesin complex | |
| membrane | |
| plasma membrane |
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm |
| GO Biological Process | intracellular protein transport |
|---|---|
| neurotransmitter transport | |
| synaptic vesicle docking | |
| exocytosis | |
| nonselective vesicle transport |
| Microarray ID | 1387359_at |
|---|---|
| 1387360_at | |
| D10392_i_at | |
| D12519_s_at | |
| 100933_at | |
| 1437390_x_at | |
| 1448366_at | |
| D45208_at | |
| msa.13479.0_s_at | |
| A_65_P10510 | |
| L0844C08-3 | |
| A_51_P182722 | |
| NM_016801 | |
| U12918 | |
| 37184_at | |
| 204729_s_at | |
| RC_AA477456_i_at | |
| RC_AA477456_s_at | |
| L37792_at | |
| A_23_P82420 | |
| I_1221821 |
| MGI ID | 109355 |
|---|
| GO Molecular Function | SNARE binding |
|---|---|
| t-SNARE activity | |
| protein transporter activity |
| GO ID | GO:0000149 |
|---|---|
| GO:0005486 | |
| GO:0008565 | |
| GO:0006886 | |
| GO:0006836 | |
| GO:0016081 | |
| GO:0005871 | |
| GO:0016020 | |
| GO:0016021 | |
| GO:0005886 | |
| GO:0006899 | |
| GO:0006887 |
| Swiss-Prot Accession | Q16623 |
|---|
| Keyword | t SNARE |
|---|---|
| toxin |
| OMIM ID | OMIM:186590 |
|---|
| Alias | Stx1a |
|---|---|
| syntaxin 1a | |
| syntaxin 1 a | |
| syntaxin 1 A (brain) | |
| HPC-1 | |
| syntaxin 1A (brain) | |
| STX1 | |
| p35-1 | |
| syn1A | |
| Neuron-specific antigen HPC I | |
| Neuron-specific antigen HPC-1 | |
| p35 I | |
| STX I |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 116470 |
|---|---|
| 20907 | |
| 6804 |
| Source | ResNet |
|---|
| RGD ID | 69430 |
|---|
| Pathway | path2 |
|---|---|
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.9943 |
|---|---|
| Mm.6225 | |
| Hs.75671 |
| Group | New Group |
|---|