Protein : STX1A

Connectivity 135
Notes Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]
Hugo ID 11433
Name STX1A
Description syntaxin 1A (brain)
URN urn:agi-llid:6804

GO Cellular Component integral to membrane
kinesin complex
membrane
plasma membrane

Cell Localization Plasma membrane
Cytoplasm

GO Biological Process intracellular protein transport
neurotransmitter transport
synaptic vesicle docking
exocytosis
nonselective vesicle transport

Microarray ID 1387359_at
1387360_at
D10392_i_at
D12519_s_at
100933_at
1437390_x_at
1448366_at
D45208_at
msa.13479.0_s_at
A_65_P10510
L0844C08-3
A_51_P182722
NM_016801
U12918
37184_at
204729_s_at
RC_AA477456_i_at
RC_AA477456_s_at
L37792_at
A_23_P82420
I_1221821

GenBank ID D10392
NT_079720
XM_347373
XP_347374
NW_047384
XM_346442
XP_346443
AF217191
AAF23017
BAA01231
D12519
BAA02089
M95734
AAA42195
NP_446240
D45208
NT_039314
NM_016801
NP_058081
BC023379
BC047133
AAH47133
BC057892
BAA28865
O35526
L37792
NT_007758
NM_004603
NP_004594
NT_079593
AB086954
BAC78519
BC000444
AAH00444
BC003011
AAH03011
D37932
BAA07151
AAA53519
U12918
AAA20940
Q16623

MGI ID 109355

GO Molecular Function SNARE binding
t-SNARE activity
protein transporter activity

GO ID GO:0000149
GO:0005486
GO:0008565
GO:0006886
GO:0006836
GO:0016081
GO:0005871
GO:0016020
GO:0016021
GO:0005886
GO:0006899
GO:0006887

Swiss-Prot Accession Q16623

Keyword t SNARE
toxin

OMIM ID OMIM:186590

Alias Stx1a
syntaxin 1a
syntaxin 1 a
syntaxin 1 A (brain)
HPC-1
syntaxin 1A (brain)
STX1
p35-1
syn1A
Neuron-specific antigen HPC I
Neuron-specific antigen HPC-1
p35 I
STX I

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 116470
20907
6804

Source ResNet

RGD ID 69430

Pathway path2
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.9943
Mm.6225
Hs.75671

Group New Group