| Connectivity | 57 |
|---|---|
| Notes | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. At least two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only one of them has been described. |
| Hugo ID | 6284 |
| Name | KCNMA1 |
| Description | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| URN | urn:agi-llid:3778 |
| GO Cellular Component | integral to membrane |
|---|---|
| integral to plasma membrane | |
| membrane | |
| voltage-gated potassium channel complex |
| Cell Localization | Plasma membrane |
|---|
| GO Biological Process | DNA methylation |
|---|---|
| cation transport | |
| ion transport | |
| potassium ion transport | |
| transport |
| Microarray ID | 1369334_at |
|---|---|
| 1370472_a_at | |
| U40603_at | |
| U55995_at | |
| AF083341_s_at | |
| U93052_s_at | |
| 97759_at | |
| 1424848_at | |
| 1425987_a_at | |
| u09383_s_at | |
| Msa.989.0_at | |
| A_51_P187352 | |
| NM_010610 | |
| U11058 | |
| U02632 | |
| 214921_at | |
| 221583_s_at | |
| 36442_g_at | |
| 40737_at | |
| 36441_at | |
| 47575_g_at | |
| 47574_at | |
| 53796_at | |
| 91355_at | |
| 221584_s_at | |
| RC_AA137034_at | |
| U02632_at | |
| U11717_s_at | |
| U13913_s_at | |
| A_23_P113856 | |
| I_1109763 | |
| A_32_P181222 | |
| I_933795 | |
| A_23_P60727 |
| MGI ID | 99923 |
|---|
| GO Molecular Function | voltage-gated ion channel activity |
|---|---|
| N-methyltransferase activity | |
| ion channel activity | |
| cation channel activity | |
| calcium-activated potassium channel activity | |
| potassium channel activity | |
| DNA binding |
| GO ID | GO:0005244 |
|---|---|
| GO:0008170 | |
| GO:0005216 | |
| GO:0005261 | |
| GO:0015269 | |
| GO:0005267 | |
| GO:0003677 | |
| GO:0006306 | |
| GO:0006812 | |
| GO:0006813 | |
| GO:0006811 | |
| GO:0016020 | |
| GO:0016021 | |
| GO:0005887 |
| Swiss-Prot Accession | Q12960 |
|---|
| OMIM ID | OMIM:600150 |
|---|
| Alias | Kcnma1 |
|---|---|
| Slo | |
| potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | |
| Slo1 | |
| mSlo | |
| MaxiK | |
| mSlo1 | |
| large conductance calcium-activated potassium channel subfamily M alpha member 1 | |
| BKCA-alpha | |
| BKTM | |
| SAKCA | |
| KCa1.1 | |
| hSlo | |
| BKCA alpha subunit | |
| Drosophila slowpoke-like | |
| stretch-activated Kca channel | |
| SLO-ALPHA | |
| calcium-activated potassium channel alpha subunit | |
| Kcnma I | |
| Kcnma3 | |
| Maxi-K | |
| mSlo I | |
| mSlo3 | |
| Potassium large conductance calcium-activated channel, subfamily M, | |
| potassium large conductance calcium-activated channel, subfamily M, alpha m | |
| potassium large conductance calcium-activated channel, ubfamily |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 83731 |
|---|---|
| 16531 | |
| 3778 | |
| 142954 |
| Source | ResNet |
|---|
| RGD ID | 620715 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.30616 |
|---|---|
| Mm.4123 | |
| Hs.354740 | |
| Rn.10280 |