| Connectivity | 29 |
|---|---|
| Notes | The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. |
| Hugo ID | 579 |
| Name | APBA2 |
| Description | amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like) |
| URN | urn:agi-llid:321 |
| GO Cellular Component | plasma membrane |
|---|
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm |
| GO Biological Process | intracellular protein transport |
|---|---|
| intracellular signaling cascade | |
| protein transport | |
| synaptic vesicle exocytosis | |
| neurogenesis | |
| pathogenesis |
| Microarray ID | 1375616_at |
|---|---|
| 1387289_at | |
| AF029107_at | |
| A_43_P12675 | |
| NM_031780 | |
| 92727_at | |
| 1427288_at | |
| L34676_rc_at | |
| Msa.1599.0_at | |
| A_51_P173851 | |
| L34676 | |
| AB014719 | |
| 209870_s_at | |
| 39590_at | |
| 209871_s_at | |
| RC_T16098_s_at | |
| RC_AA598991_at | |
| U79255_at | |
| A_23_P158231 | |
| I_1221912 |
| MGI ID | 1261791 |
|---|
| GO Molecular Function | protein transporter activity |
|---|---|
| protein binding | |
| amyloid protein |
| GO ID | GO:0008565 |
|---|---|
| GO:0015031 | |
| GO:0006886 | |
| GO:0007242 | |
| GO:0005515 | |
| GO:0005208 | |
| GO:0009405 | |
| GO:0007399 |
| Swiss-Prot Accession | Q99767 |
|---|
| OMIM ID | OMIM:602712 |
|---|
| Alias | Apba2 |
|---|---|
| Mint2 | |
| amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like) | |
| X11L | |
| X11-like | |
| amyloid beta (A4) precursor protein-binding, family A, member 2 | |
| LIN-10 | |
| X11-like protein | |
| adapter protein X11beta | |
| neuron-specific X11L protein | |
| neuronal munc18-1-interacting protein 2 | |
| amyloid beta A4 precursor protein-binding, family A, member 2 | |
| phosphotyrosine-binding/-interacting domain (PTB)-bearing protein | |
| HsT16821 | |
| D15S1518E | |
| MGC:14091 | |
| LIN X | |
| Mint II | |
| Mint-2 | |
| Munc18-1-interacting protein 2 | |
| Munc18-1-interacting protein II | |
| Munc18-1-interactive protein 2 | |
| Munc18-1-interactive protein II | |
| Neuron- specific X11L protein | |
| Neuronal Munc18-1-interacting protein II | |
| Neuronal Munc18-1-interactive protein 2 | |
| Neuronal Munc18-1-interactive protein II |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 83610 |
|---|---|
| 11784 | |
| 321 | |
| 9029 |
| Source | ResNet |
|---|
| RGD ID | 620845 |
|---|
| Pathway | path |
|---|---|
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.62687 |
|---|---|
| Mm.4657 | |
| Hs.26468 |
| Group | protein binding |
|---|---|
| New Group |