| Connectivity | 565 |
|---|---|
| Notes | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. |
| Hugo ID | 1748 |
| Name | CDH1 |
| Description | cadherin 2, type 1, N-cadherin |
| URN | urn:agi-llid:999 |
| GO Cellular Component | adherens junction |
|---|---|
| apical part of cell | |
| cell-cell adherens junction | |
| extracellular space | |
| integral to membrane | |
| membrane | |
| plasma membrane |
| Cell Localization | Plasma membrane |
|---|
| GO Biological Process | synaptogenesis |
|---|---|
| cell adhesion | |
| homophilic cell adhesion | |
| protein metabolism |
| Microarray ID | 1386947_at |
|---|---|
| rc_AA946081_s_at | |
| A_43_P12556 | |
| NM_031334 | |
| 98140_at | |
| 1448261_at | |
| x06115_s_at | |
| Msa.2268.0_at | |
| A_65_P08886 | |
| H3050H02-3 | |
| A_51_P137336 | |
| NM_009864 | |
| Z13009 | |
| 2082_s_at | |
| 977_s_at | |
| 201130_s_at | |
| 201131_s_at | |
| 213084_x_at | |
| 208834_x_at | |
| Z35402_rna1_s_at | |
| A_23_P206359 | |
| I_958805 |
| MGI ID | 88354 |
|---|
| GO Molecular Function | protein binding |
|---|---|
| calcium ion binding | |
| cell adhesion molecule activity | |
| protein homooligomerization activity | |
| calcium-dependent cell adhesion molecule activity | |
| tumor suppressor |
| GO ID | GO:0007416 |
|---|---|
| GO:0005515 | |
| GO:0005509 | |
| GO:0005194 | |
| GO:0042804 | |
| GO:0007156 | |
| GO:0007155 | |
| GO:0019538 | |
| GO:0016020 | |
| GO:0005913 | |
| GO:0016021 | |
| GO:0005615 | |
| GO:0005886 | |
| GO:0008014 | |
| GO:0008181 |
| Swiss-Prot Accession | P12830 |
|---|
| Keyword | adherens junction |
|---|---|
| metalloproteinase | |
| actin | |
| intercellular junction | |
| cytoskeleton |
| OMIM ID | OMIM:192090 |
|---|---|
| OMIM:137215 |
| Alias | Cdh1 |
|---|---|
| cadherin 1 | |
| E-cadherin | |
| Um | |
| UVO | |
| Ecad | |
| uvomorulin | |
| CDHE | |
| LCAM | |
| CAD1 | |
| cadherin 1, type 1, E-cadherin (epithelial) | |
| Arc-1 | |
| cell-CAM 120/80 | |
| cadherin 1, E-cadherin (epithelial) | |
| calcium-dependent adhesion protein, epithelial | |
| cadherin 1, type 1 preproprotein | |
| CAD1_HUMAN | |
| cadherin 1 precursor | |
| Arc I | |
| CAD I | |
| CAM 120/80 | |
| Cdh I | |
| Epithelial-cadherin precursor |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 83502 |
|---|---|
| 12550 | |
| 101988 | |
| 999 |
| Source | ResNet |
|---|
| RGD ID | 69279 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.1303 |
|---|---|
| Mm.35605 | |
| Hs.194657 |
| Group | protein binding |
|---|---|
| metal ion binding |