| Connectivity | 373 |
|---|---|
| Notes | Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM] |
| Hugo ID | 4390 |
| Name | GNAQ |
| Description | guanine nucleotide binding protein (G protein), q polypeptide |
| URN | urn:agi-llid:2776 |
| GO Cellular Component | heterotrimeric G-protein complex |
|---|---|
| cytoplasm | |
| plasma membrane |
| Cell Localization | Cytoplasm |
|---|---|
| Plasma membrane |
| GO Biological Process | G-protein coupled receptor protein signaling pathway |
|---|---|
| signal transduction | |
| G-protein signaling, adenylate cyclase activating pathway | |
| glutamate signaling pathway | |
| heart development | |
| neuronal remodeling | |
| protein amino acid ADP-ribosylation | |
| regulation of action potential | |
| skeletal development | |
| phospholipase C activation |
| MGI ID | 95776 |
|---|
| Swiss-Prot Accession | P50148 |
|---|
| OMIM ID | OMIM:600998 |
|---|
| Alias | Gnaq |
|---|---|
| heterotrimeric guanine nucleotide-binding protein alpha q subunit | |
| Gq | |
| Galphaq | |
| guanine nucleotide binding protein, alpha q polypeptide | |
| G alpha q | |
| 1110005L02Rik | |
| 6230401I02Rik | |
| G-ALPHA-q | |
| guanine nucleotide binding protein (G protein), q polypeptide | |
| G(q), alpha | |
| G(q), alpha subunit | |
| Guanine nucleotide-binding protein G(q), alpha subunit | |
| heterotrimeric guanine nucleotide-binding protein alpha q subuni | |
| RIKEN cDNA 1110005L02 gene | |
| RIKEN cDNA 6230401I02 gene | |
| GAQ | |
| G protein q polypeptide | |
| (G PROTEIN), Q POLYPEPTIDE |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 81666 |
|---|---|
| 14682 | |
| 67782 | |
| 71788 | |
| 107077 | |
| 107345 | |
| 158254 |
| RGD ID | 620770 |
|---|
| Pathway | Copy of 'path8' |
|---|---|
| path8 | |
| pathfeb |
| Unigene ID | Rn.22817 |
|---|---|
| Mm.275685 | |
| Hs.469951 |
| Group | nucleotide binding |
|---|---|
| New Group |