| Connectivity | 14 |
|---|---|
| Notes | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. |
| Hugo ID | 3389 |
| Name | EPHA5 |
| Description | EphA5 |
| URN | urn:agi-llid:2044 |
| GO Cellular Component | integral to membrane |
|---|---|
| membrane |
| Cell Localization | Plasma membrane |
|---|
| GO Biological Process | protein amino acid phosphorylation |
|---|---|
| transmembrane receptor protein tyrosine kinase signaling pathway |
| EC Number | 2.7.1.112 |
|---|
| Microarray ID | 1371007_at |
|---|---|
| rc_AI231376_at | |
| X78689cds_at | |
| A_42_P498708 | |
| 286993_Rn | |
| 98376_at | |
| 161119_at | |
| 98377_at | |
| 98378_g_at | |
| 1420557_at | |
| U07357_s_at | |
| Msa.204.0_at | |
| A_51_P128174 | |
| NM_007937 | |
| AF101726 | |
| 216837_at | |
| 215664_s_at | |
| 238241_at | |
| 34564_at | |
| 80453_at | |
| 1605_g_at | |
| L36644_at | |
| X95425_s_at | |
| 1604_AT | |
| A_23_P147834 | |
| I_1152288 | |
| A_23_P72340 | |
| I_1000650 |
| State | ephrin receptor isoform a |
|---|---|
| ephrin receptor isoform b |
| State Description | Transcript Variant: This variant (1) encodes the longer isoform (a). |
|---|---|
| Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b) that has a shorter C-terminus. |
| MGI ID | 99654 |
|---|
| GO Molecular Function | ephrin receptor activity |
|---|---|
| protein-tyrosine kinase activity | |
| ATP binding | |
| protein serine/threonine kinase activity | |
| receptor activity | |
| protein kinase activity | |
| kinase activity | |
| transferase activity | |
| transmembrane-ephrin receptor activity |
| GO ID | GO:0005003 |
|---|---|
| GO:0004713 | |
| GO:0005524 | |
| GO:0004674 | |
| GO:0004872 | |
| GO:0004672 | |
| GO:0016301 | |
| GO:0016740 | |
| GO:0007169 | |
| GO:0006468 | |
| GO:0016020 | |
| GO:0016021 | |
| GO:0005005 |
| Swiss-Prot Accession | P54756 |
|---|
| Keyword | receptor protein tyrosine kinase |
|---|
| OMIM ID | OMIM:600004 |
|---|
| Alias | Els1 |
|---|---|
| eck-like sequence 1 | |
| Epha5 | |
| bsk | |
| Cek7 | |
| Ehk1 | |
| Hek7 | |
| Rek7 | |
| Els | |
| Eph receptor A5 | |
| Eph homology kinase-1 | |
| ephrin type-A receptor 5 | |
| receptor protein-tyrosine kinase HEK7 | |
| tyrosine-protein kinase receptor EHK-1 | |
| AI854630 | |
| eck-like sequence I | |
| EHK I | |
| Els I | |
| Eph homology kinase I | |
| ephrin receptor EphA5 | |
| Ephrin type-A receptor V | |
| expressed sequence AI854630 | |
| Receptor protein- tyrosine kinase HEK7 | |
| similar to receptor tyrosine kinase Ehk I | |
| similar to receptor tyrosine kinase Ehk-1 | |
| TYRO4 | |
| TYRO4 protein tyrosine kinase | |
| Tyrosine-protein kinase receptor EHK I | |
| Tyrosine-protein kinase receptor EHK-1 | |
| similar to receptor tyrosine kinase Ehk-1 - rat |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 79208 |
|---|---|
| 13718 | |
| 13839 | |
| 100769 | |
| 2044 | |
| 7304 |
| Source | ResNet |
|---|
| RGD ID | 620831 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.24569 |
|---|---|
| Mm.137991 | |
| Hs.201920 | |
| Mm.4466 |
| Group | nucleotide binding |
|---|