| Connectivity | 110 |
|---|---|
| Notes | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
| Hugo ID | 9670 |
| Name | PTPRF |
| Description | protein tyrosine phosphatase, receptor type, F |
| URN | urn:agi-llid:5792 |
| GO Cellular Component | extracellular space |
|---|---|
| integral to membrane | |
| integral to plasma membrane | |
| plasma membrane | |
| nucleus |
| Cell Localization | Plasma membrane |
|---|
| GO Biological Process | homophilic cell adhesion |
|---|---|
| neurogenesis | |
| cell adhesion | |
| protein amino acid dephosphorylation | |
| transmembrane receptor protein tyrosine phosphatase signaling pathway |
| EC Number | 3.1.3.48 |
|---|
| Microarray ID | 1368035_a_at |
|---|---|
| 1368036_at | |
| M60103_at | |
| X83546_at | |
| 1371086_at | |
| 96272_at | |
| 1420841_at | |
| 1420842_at | |
| 1420843_at | |
| 109849_f_at | |
| 165261_i_at | |
| aa048018_s_at | |
| Msa.16718.0_s_at | |
| Msa.23615.0_s_at | |
| Msa.16718.0_at | |
| Msa.23615.0_at | |
| Msa.43192.0_at | |
| Msa.43192.0_g_at | |
| msa.11743.0_at | |
| msa.30154.0_s_at | |
| A_51_P466478 | |
| NM_011213 | |
| A_65_P08637 | |
| L0031B05-3 | |
| A_65_P14341 | |
| L0265C11-3 | |
| Y00815 | |
| 200635_s_at | |
| 200637_s_at | |
| 36204_at | |
| 200636_s_at | |
| Y00815_at | |
| 1264_AT | |
| 1265_G_AT | |
| A_32_P416233 | |
| I_2016274 | |
| A_23_P200989 | |
| I_931679 |
| State | isoform 1 precursor |
|---|---|
| isoform 2 precursor |
| State Description | Transcript Variant: This variant (1) contains an extra internal fragment within the coding region when compared to variant 2. It thus encodes a protein that has a 9 aa internal fragment absent in isoform 2. |
|---|---|
| Transcript Variant: This variant (2) lacks an internal fragment within the coding region when compared to variant 1. It thus encodes a protein that lacks a 9 aa internal fragment present in isoform 1. |
| MGI ID | 102695 |
|---|
| GO Molecular Function | transmembrane receptor protein tyrosine phosphatase activity |
|---|---|
| protein phosphatase activity | |
| receptor activity | |
| cell adhesion molecule activity | |
| protein tyrosine phosphatase activity | |
| prenylated protein tyrosine phosphatase activity | |
| hydrolase activity |
| GO ID | GO:0005001 |
|---|---|
| GO:0004721 | |
| GO:0004872 | |
| GO:0005194 | |
| GO:0004725 | |
| GO:0004727 | |
| GO:0016787 | |
| GO:0007185 | |
| GO:0007155 | |
| GO:0006470 | |
| GO:0016021 | |
| GO:0005887 | |
| GO:0005615 | |
| GO:0005886 |
| Swiss-Prot Accession | P10586 |
|---|
| Keyword | protein-tyrosine phosphatase |
|---|---|
| 3.1.3.48 |
| OMIM ID | OMIM:179590 |
|---|
| Alias | Ptprf |
|---|---|
| LARFN5C | |
| protein tyrosine phosphatase, receptor type, F | |
| leukocyte antigen-related (LAR) PTP receptor | |
| protein tyrosine phosphatase receptor-type F | |
| protein tyrosine phosphatase, receptor-type, F | |
| LAR | |
| LARS | |
| LCA-homolog | |
| leukocyte antigen-related tyrosine phosphatase | |
| receptor-linked protein-tyrosine phosphatase LAR | |
| protein tyrosine phosphatase, receptor type, F polypeptide | |
| LAR protein precursor | |
| Leukocyte antigen related |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 29615 |
|---|---|
| 19268 | |
| 100011 | |
| 5792 |
| Source | ResNet |
|---|
| RGD ID | 3453 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.11386 |
|---|---|
| Mm.29855 | |
| Hs.75216 |
| Group | Receptors |
|---|---|
| protein binding | |
| nucleic acid binding | |
| New Group |