| Connectivity | 20 |
|---|---|
| Notes | The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Hugo ID | 814 |
| Name | ATP2B1 |
| Description | ATPase, Ca++ transporting, plasma membrane 1 |
| URN | urn:agi-llid:490 |
| GO Cellular Component | integral to membrane |
|---|---|
| membrane | |
| integral to plasma membrane |
| Cell Localization | Plasma membrane |
|---|
| GO Biological Process | calcium ion transport |
|---|---|
| cation transport | |
| metabolism | |
| transport |
| EC Number | 3.6.3.8 |
|---|
| Microarray ID | 1370050_at |
|---|---|
| rc_AI103671_at | |
| rc_AI172499_at | |
| rc_AA943827_at | |
| 1386426_at | |
| l04739cds_s_at | |
| A_43_P12761 | |
| NM_053311 | |
| J04027 | |
| 37661_at | |
| 61289_at | |
| 209281_s_at | |
| 212930_at | |
| 34188_at | |
| J04027_at | |
| 215716_s_at | |
| A_23_P128319 | |
| I_932636 |
| GenBank ID | J03753 |
|---|---|
| NW_047774 | |
| NM_053311 | |
| NP_445763 | |
| AAA73898 | |
| U16707 | |
| J04027 | |
| NT_019546 | |
| NM_001682 | |
| NP_001673 | |
| L14561 | |
| AAD09924 | |
| AAD09925 | |
| AAA74511 | |
| M95541 | |
| AAA35999 | |
| M95542 | |
| AAA36000 | |
| P20020 |
| State | plasma membrane calcium ATPase 1 isoform 1a |
|---|---|
| plasma membrane calcium ATPase 1 isoform 1b |
| State Description | Transcript Variant: This variant (1) represents the longer transcript, but encodes the shorter isoform (1a), also known as hPMCA1a. |
|---|---|
| Transcript Variant: This variant (2) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (1b) contains a longer and distinct C-terminus compared to isoform 1a. |
| MGI ID | 104653 |
|---|
| GO Molecular Function | ATP binding |
|---|---|
| calcium-transporting ATPase activity | |
| calmodulin binding | |
| magnesium ion binding | |
| ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | |
| hydrolase activity |
| GO ID | GO:0005524 |
|---|---|
| GO:0005388 | |
| GO:0005516 | |
| GO:0000287 | |
| GO:0015662 | |
| GO:0016787 | |
| GO:0006812 | |
| GO:0006816 | |
| GO:0008152 | |
| GO:0016020 | |
| GO:0016021 | |
| GO:0006810 | |
| GO:0005887 |
| Swiss-Prot Accession | P20020 |
|---|
| OMIM ID | OMIM:108731 |
|---|
| Alias | Atp2b1 |
|---|---|
| ATPase, Ca++ transporting, plasma membrane 1 | |
| plasma membrane calcium ATPase 1 | |
| PMCA1 | |
| 2810442I22Rik | |
| Atp2b I | |
| ATPase, Ca++ transporting, plasma membrane I | |
| Plasma membrane calcium ATPase isoform 1 | |
| Plasma membrane calcium ATPase isoform I | |
| plasma membrane calcium ATPase 1 isoform 1b | |
| Plasma membrane calcium pump isoform 1 | |
| Plasma membrane calcium pump isoform I | |
| Plasma membrane calcium-transporting ATPase 1 | |
| Plasma membrane calcium-transporting ATPase I | |
| PMCA I | |
| RIKEN cDNA 2810442I22 gene | |
| ATPase, Ca++ transporting, plasma membrane |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Human |
| LocusLink ID | 29598 |
|---|---|
| 11940 | |
| 490 |
| Source | ResNet |
|---|
| RGD ID | 621303 |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Rn.7208 |
|---|---|
| Hs.20952 |
| Group | nucleotide binding |
|---|---|
| protein binding | |
| metal ion binding | |
| hydrolase activity |