Protein : GRIN1

Connectivity 277
Notes The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.
Hugo ID 4584
Name GRIN1
Description glutamate receptor, ionotropic, N-methyl D-aspartate 1
URN urn:agi-llid:2902

GO Cellular Component N-methyl-D-aspartate selective glutamate receptor complex
cytoplasm
extracellular space
integral to membrane
membrane
membrane fraction
synaptic vesicle
postsynaptic membrane
dendrite
growth cone
integral to plasma membrane

Cell Localization Plasma membrane

GO Biological Process ion transport
learning and/or memory
potassium ion transport
synaptic transmission
transport
calcium ion homeostasis
cation transport
glutamate signaling pathway
regulation of synaptic plasticity
response to ethanol
small molecule transport

Microarray ID 1368572_a_at
L19708_at
U11418_s_at
l08228exon#22_s_at
s39221_g_at
A_43_P11774
NM_017010
104684_at
104685_g_at
104686_at
1437968_at
1450202_at
D10028_s_at
Msa.157.0_at
A_51_P234001
NM_008169
A_65_P18935
L0807B04-3
L05666
37135_f_at
37134_f_at
205914_s_at
205915_x_at
211125_x_at
210782_x_at
210781_x_at
L13266_s_at
219899_x_at
A_23_P96071
I_965877
A_23_P84670
I_962750
A_23_P113872
I_962709
A_23_P257407
I_964415

GenBank ID X63255
NW_047651
NM_017010
NP_058706
U08261
AAB50926
U08262
AAB50927
U08263
AAB50928
U08264
AAB50929
U08265
AAB50930
U08266
AAB50931
U08267
AAB50932
U08268
AAB50933
U11418
AAA19659
CAA44914
X65227
CAA46335
D10028
NT_039206
NM_008169
NP_032195
AK036204
BAC29347
AK090286
BC039157
AAH39157
BAA00920
P35438
L13266
L13268
L13267
NT_024000
NM_000832
NP_000823
NM_007327
NP_015566
NM_021569
NP_067544
AF015730
AAB67723
AF015731
AAB67724
D13515
BAA02732
L05666
AAA21180
AAB59360
AAA36198
AAB59361
S57708
AAB25917
U08106
AAA62111
U08107
AAA62112
AAF25205
BC015735

State NMDA receptor 1 isoform NR1-1 precursor
NMDA receptor 1 isoform NR1-3 precursor
NMDA receptor 1 isoform NR1-2 precursor

State Description Transcript Variant: This variant, NR1-1, is missing exon 20 and is alternately spliced in exon 21, leading to the short isoform NR1-1 which has a different C-terminus.
Transcript Variant: This variant, NR1-3, includes all 21 exons with alternate splicing on exon 21 matching that of transcript variant NR1-2, resulting in the long isoform.
Transcript Variant: This variant, NR1-2, is missing exon 20 and is spliced in exon 21 identical to NR1-3, leading to the medium isoform NR1-2. The partial cDNA was extended 5' using sequence from the short isoform, assuming identical N-terminal CDS and...

MGI ID 95819

GO Molecular Function glutamate-gated ion channel activity
ion channel activity
potassium channel activity
transporter activity
inotropic glutamate receptor activity
receptor activity
magnesium ion binding
protein binding
receptor binding
N-methyl-D-aspartate selective glutamate receptor activity

GO ID GO:0005234
GO:0005216
GO:0005267
GO:0005215
GO:0004970
GO:0004872
GO:0000287
GO:0006813
GO:0006810
GO:0006811
GO:0007268
GO:0016020
GO:0008021
GO:0016021
GO:0005615
GO:0005737
GO:0005624
GO:0005515
GO:0005102
GO:0045211
GO:0004972
GO:0006832
GO:0007215
GO:0005887

Swiss-Prot Accession Q05586

Keyword NMDA receptor
receptor antagonist
dendrite

OMIM ID OMIM:138249

Alias Grin1
NR1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
N-methyl-D-aspartate receptor
Nmdar
NMDAR1
GluRdelta1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
NMDA1
NR1-3
NMDA1-3
glutamate [NMDA] receptor subunit zeta 1
N-methyl-D-aspartate receptor channel, subunit zeta-1
NR1a
GluRdelta I
glutamate (NMDA) receptor subunit zeta 1
glutamate (NMDA) receptor subunit zeta I
Glutamate NMDA receptor 1
Glutamate NMDA receptor I
glutamate receptor, ionotropic, N-methyl D-aspartate I
Grin I
NMDA I
NMDA receptor 1 isoform NR1-1 precursor
NMDA receptor 1 isoform NR1-2 precursor
NMDA receptor 1 isoform NR1-3 precursor
NMDAR I
N-methyl-D-aspartate receptor channel, subunit zeta I
NR1 I
NR1 II
NR1 III
NR1-1
NR1-2
glutamate receptor, ionotropic, N-methyl D-aspartate
N-methyl-D-aspartate receptor channel, subunit zeta-
NR I

Organism Rattus norvegicus
Mus musculus
Human

LocusLink ID 24408
60392
14810
2902

Source ResNet

RGD ID 2736

Pathway path
path2
path1
path3
path4
path5
path6
path7
Copy of 'path8'
path8
pathfeb

Unigene ID Rn.9840
Mm.278672
Hs.105
Mm.3292

Group Receptors
metal ion binding
amino acid binding