Connectivity | 277 |
---|---|
Notes | The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. |
Hugo ID | 4584 |
Name | GRIN1 |
Description | glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
URN | urn:agi-llid:2902 |
GO Cellular Component | N-methyl-D-aspartate selective glutamate receptor complex |
---|---|
cytoplasm | |
extracellular space | |
integral to membrane | |
membrane | |
membrane fraction | |
synaptic vesicle | |
postsynaptic membrane | |
dendrite | |
growth cone | |
integral to plasma membrane |
Cell Localization | Plasma membrane |
---|
GO Biological Process | ion transport |
---|---|
learning and/or memory | |
potassium ion transport | |
synaptic transmission | |
transport | |
calcium ion homeostasis | |
cation transport | |
glutamate signaling pathway | |
regulation of synaptic plasticity | |
response to ethanol | |
small molecule transport |
Microarray ID | 1368572_a_at |
---|---|
L19708_at | |
U11418_s_at | |
l08228exon#22_s_at | |
s39221_g_at | |
A_43_P11774 | |
NM_017010 | |
104684_at | |
104685_g_at | |
104686_at | |
1437968_at | |
1450202_at | |
D10028_s_at | |
Msa.157.0_at | |
A_51_P234001 | |
NM_008169 | |
A_65_P18935 | |
L0807B04-3 | |
L05666 | |
37135_f_at | |
37134_f_at | |
205914_s_at | |
205915_x_at | |
211125_x_at | |
210782_x_at | |
210781_x_at | |
L13266_s_at | |
219899_x_at | |
A_23_P96071 | |
I_965877 | |
A_23_P84670 | |
I_962750 | |
A_23_P113872 | |
I_962709 | |
A_23_P257407 | |
I_964415 |
State | NMDA receptor 1 isoform NR1-1 precursor |
---|---|
NMDA receptor 1 isoform NR1-3 precursor | |
NMDA receptor 1 isoform NR1-2 precursor |
State Description | Transcript Variant: This variant, NR1-1, is missing exon 20 and is alternately spliced in exon 21, leading to the short isoform NR1-1 which has a different C-terminus. |
---|---|
Transcript Variant: This variant, NR1-3, includes all 21 exons with alternate splicing on exon 21 matching that of transcript variant NR1-2, resulting in the long isoform. | |
Transcript Variant: This variant, NR1-2, is missing exon 20 and is spliced in exon 21 identical to NR1-3, leading to the medium isoform NR1-2. The partial cDNA was extended 5' using sequence from the short isoform, assuming identical N-terminal CDS and... |
MGI ID | 95819 |
---|
GO Molecular Function | glutamate-gated ion channel activity |
---|---|
ion channel activity | |
potassium channel activity | |
transporter activity | |
inotropic glutamate receptor activity | |
receptor activity | |
magnesium ion binding | |
protein binding | |
receptor binding | |
N-methyl-D-aspartate selective glutamate receptor activity |
GO ID | GO:0005234 |
---|---|
GO:0005216 | |
GO:0005267 | |
GO:0005215 | |
GO:0004970 | |
GO:0004872 | |
GO:0000287 | |
GO:0006813 | |
GO:0006810 | |
GO:0006811 | |
GO:0007268 | |
GO:0016020 | |
GO:0008021 | |
GO:0016021 | |
GO:0005615 | |
GO:0005737 | |
GO:0005624 | |
GO:0005515 | |
GO:0005102 | |
GO:0045211 | |
GO:0004972 | |
GO:0006832 | |
GO:0007215 | |
GO:0005887 |
Swiss-Prot Accession | Q05586 |
---|
Keyword | NMDA receptor |
---|---|
receptor antagonist | |
dendrite |
OMIM ID | OMIM:138249 |
---|
Alias | Grin1 |
---|---|
NR1 | |
glutamate receptor, ionotropic, N-methyl D-aspartate 1 | |
N-methyl-D-aspartate receptor | |
Nmdar | |
NMDAR1 | |
GluRdelta1 | |
glutamate receptor, ionotropic, NMDA1 (zeta 1) | |
NMDA1 | |
NR1-3 | |
NMDA1-3 | |
glutamate [NMDA] receptor subunit zeta 1 | |
N-methyl-D-aspartate receptor channel, subunit zeta-1 | |
NR1a | |
GluRdelta I | |
glutamate (NMDA) receptor subunit zeta 1 | |
glutamate (NMDA) receptor subunit zeta I | |
Glutamate NMDA receptor 1 | |
Glutamate NMDA receptor I | |
glutamate receptor, ionotropic, N-methyl D-aspartate I | |
Grin I | |
NMDA I | |
NMDA receptor 1 isoform NR1-1 precursor | |
NMDA receptor 1 isoform NR1-2 precursor | |
NMDA receptor 1 isoform NR1-3 precursor | |
NMDAR I | |
N-methyl-D-aspartate receptor channel, subunit zeta I | |
NR1 I | |
NR1 II | |
NR1 III | |
NR1-1 | |
NR1-2 | |
glutamate receptor, ionotropic, N-methyl D-aspartate | |
N-methyl-D-aspartate receptor channel, subunit zeta- | |
NR I |
Organism | Rattus norvegicus |
---|---|
Mus musculus | |
Human |
LocusLink ID | 24408 |
---|---|
60392 | |
14810 | |
2902 |
Source | ResNet |
---|
RGD ID | 2736 |
---|
Pathway | path |
---|---|
path2 | |
path1 | |
path3 | |
path4 | |
path5 | |
path6 | |
path7 | |
Copy of 'path8' | |
path8 | |
pathfeb |
Unigene ID | Rn.9840 |
---|---|
Mm.278672 | |
Hs.105 | |
Mm.3292 |
Group | Receptors |
---|---|
metal ion binding | |
amino acid binding |