Protein : GRIN1


Connectivity	277
Notes	The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.
Hugo ID	4584
Name	GRIN1
Description	glutamate receptor, ionotropic, N-methyl D-aspartate 1
URN	urn:agi-llid:2902


GO Cellular Component	N-methyl-D-aspartate selective glutamate receptor complex
	cytoplasm
	extracellular space
	integral to membrane
	membrane
	membrane fraction
	synaptic vesicle
	postsynaptic membrane
	dendrite
	growth cone
	integral to plasma membrane


Cell Localization	Plasma membrane


GO Biological Process	ion transport
	learning and/or memory
	potassium ion transport
	synaptic transmission
	transport
	calcium ion homeostasis
	cation transport
	glutamate signaling pathway
	regulation of synaptic plasticity
	response to ethanol
	small molecule transport


State	NMDA receptor 1 isoform NR1-1 precursor
	NMDA receptor 1 isoform NR1-3 precursor
	NMDA receptor 1 isoform NR1-2 precursor


State Description	Transcript Variant: This variant, NR1-1, is missing exon 20 and is alternately spliced in exon 21, leading to the short isoform NR1-1 which has a different C-terminus.
	Transcript Variant: This variant, NR1-3, includes all 21 exons with alternate splicing on exon 21 matching that of transcript variant NR1-2, resulting in the long isoform.
	Transcript Variant: This variant, NR1-2, is missing exon 20 and is spliced in exon 21 identical to NR1-3, leading to the medium isoform NR1-2. The partial cDNA was extended 5' using sequence from the short isoform, assuming identical N-terminal CDS and...


MGI ID	95819


GO Molecular Function	glutamate-gated ion channel activity
	ion channel activity
	potassium channel activity
	transporter activity
	inotropic glutamate receptor activity
	receptor activity
	magnesium ion binding
	protein binding
	receptor binding
	N-methyl-D-aspartate selective glutamate receptor activity


Swiss-Prot Accession	Q05586


OMIM ID	OMIM:138249


Alias	Grin1
	NR1
	glutamate receptor, ionotropic, N-methyl D-aspartate 1
	N-methyl-D-aspartate receptor
	Nmdar
	NMDAR1
	GluRdelta1
	glutamate receptor, ionotropic, NMDA1 (zeta 1)
	NMDA1
	NR1-3
	NMDA1-3
	glutamate [NMDA] receptor subunit zeta 1
	N-methyl-D-aspartate receptor channel, subunit zeta-1
	NR1a
	GluRdelta I
	glutamate (NMDA) receptor subunit zeta 1
	glutamate (NMDA) receptor subunit zeta I
	Glutamate NMDA receptor 1
	Glutamate NMDA receptor I
	glutamate receptor, ionotropic, N-methyl D-aspartate I
	Grin I
	NMDA I
	NMDA receptor 1 isoform NR1-1 precursor
	NMDA receptor 1 isoform NR1-2 precursor
	NMDA receptor 1 isoform NR1-3 precursor
	NMDAR I
	N-methyl-D-aspartate receptor channel, subunit zeta I
	NR1 I
	NR1 II
	NR1 III
	NR1-1
	NR1-2
	glutamate receptor, ionotropic, N-methyl D-aspartate
	N-methyl-D-aspartate receptor channel, subunit zeta-
	NR I


Source	ResNet


RGD ID	2736