| Connectivity | 18 |
|---|---|
| Notes | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. |
| Hugo ID | 6866 |
| Name | MAP4K4 |
| Description | mitogen-activated protein kinase kinase kinase kinase 4 |
| URN | urn:agi-llid:9448 |
| GO Cellular Component | cellular_component unknown |
|---|
| Cell Localization | Cytoplasm |
|---|
| GO Biological Process | protein amino acid phosphorylation |
|---|---|
| protein kinase cascade | |
| response to stress |
| Microarray ID | 102195_at |
|---|---|
| 1422615_at | |
| 102601_f_at | |
| 161295_r_at | |
| U88984_s_at | |
| 1448050_s_at | |
| A_51_P268053 | |
| NM_008696 | |
| A_65_P06571 | |
| H3105G04-3 | |
| 35694_at | |
| 91812_at | |
| 206571_s_at | |
| 222547_at | |
| 222548_s_at | |
| 86235_at | |
| RC_N54067_at | |
| A_32_P440373 | |
| I_3285480 | |
| A_23_P108604 | |
| I_939089 |
| State | isoform 1 |
|---|---|
| isoform 2 | |
| isoform 3 |
| State Description | Transcript Variant: This variant (1) lacks two in-frame coding segments, and contains an extra in-frame coding segment, compared to variant 2. The resulting isoform (1) thus lacks two regions, and contains an additional region, as compared to isoform 2. |
|---|---|
| Transcript Variant: This variant (2) encodes the longest isoform (2). | |
| Transcript Variant: This variant (3) lacks two in-frame coding segments compared to variant 2. The resulting isoform (3) thus lacks two regions, as compared to isoform 2. |
| MGI ID | 1349394 |
|---|
| GO Molecular Function | small GTPase regulatory/interacting protein activity |
|---|---|
| protein-tyrosine kinase activity | |
| ATP binding | |
| protein serine/threonine kinase activity | |
| protein kinase activity | |
| transferase activity |
| GO ID | GO:0005083 |
|---|---|
| GO:0004713 | |
| GO:0005524 | |
| GO:0004674 | |
| GO:0004672 | |
| GO:0016740 | |
| GO:0006468 | |
| GO:0007243 | |
| GO:0006950 | |
| GO:0008372 |
| Swiss-Prot Accession | O95819 |
|---|
| OMIM ID | OMIM:604666 |
|---|
| Alias | Map4k4 |
|---|---|
| HGK | |
| Nik | |
| mitogen-activated protein kinase kinase kinase kinase 4 | |
| HPK/GCK-like kinase | |
| NCK interacting kinase | |
| AU045934 | |
| expressed sequence AU045934 | |
| hepatocyte progenitor kinase-like/germinal center kinase-like kinase | |
| FLH21957 | |
| FLJ20373 | |
| KIAA0687 | |
| MAPKKKK4 | |
| mitogen-activated protein kinase kinase kinase kinase IV | |
| Nesk | |
| Nik related kinase | |
| hypothetical protein FLJ20373 |
| Organism | Mus musculus |
|---|---|
| Human |
| LocusLink ID | 18078 |
|---|---|
| 26921 | |
| 98612 | |
| 9448 | |
| 54912 |
| Source | ResNet |
|---|
| Pathway | path |
|---|---|
| path2 | |
| path1 | |
| path3 | |
| path4 | |
| path5 | |
| path6 | |
| path7 | |
| Copy of 'path8' | |
| path8 | |
| pathfeb |
| Unigene ID | Mm.19073 |
|---|---|
| Hs.531607 | |
| Mm.987 | |
| Hs.3628 |
| Group | Kinases |
|---|---|
| nucleotide binding |